{"id":2395,"date":"2023-08-31T09:11:07","date_gmt":"2023-08-31T09:11:07","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=2395"},"modified":"2026-05-04T08:45:40","modified_gmt":"2026-05-04T08:45:40","slug":"06-theme","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/06-theme\/","title":{"rendered":"06-Theme"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2395\" class=\"elementor elementor-2395\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca9e50e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca9e50e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"make-column-clickable-elementor elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-fc34845\" data-column-clickable=\"https:\/\/ctmtest2.fr\/01-menu\/\" data-column-clickable-blank=\"_self\" data-id=\"fc34845\" data-element_type=\"column\" data-e-type=\"column\"><a href=\"https:\/\/ctmtest2.fr\/01-menu\/\" class=\"make-column-clickable-link\"><span class=\"make-column-clickable-text\">Retour<\/span><\/a>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-634f7aa elementor-widget elementor-widget-button\" data-id=\"634f7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/06-menu\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Retour<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-253fdf7\" data-id=\"253fdf7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6e39dc elementor-widget elementor-widget-heading\" data-id=\"a6e39dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-xl\">PADYS : T. JOURDAN<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20e3194 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"20e3194\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b806867\" data-id=\"b806867\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-714b078 hfe-menu-item-flex-end hfe-submenu-icon-arrow hfe-link-redirect-child elementor-widget elementor-widget-navigation-menu\" data-id=\"714b078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;hamburger_menu_align&quot;:&quot;flex-end&quot;,&quot;padding_horizontal_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;20&quot;,&quot;sizes&quot;:[]},&quot;hamburger_align&quot;:&quot;center&quot;,&quot;dropdown_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;padding_horizontal_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_horizontal_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"navigation-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"hfe-nav-menu hfe-layout-expandible hfe-nav-menu-layout expandible\" data-layout=\"expandible\">\n\t\t\t\t<div role=\"button\" class=\"hfe-nav-menu__toggle elementor-clickable\" tabindex=\"0\" aria-label=\"Basculer le menu\">\n\t\t\t\t\t<span class=\"screen-reader-text\">Menu<\/span>\n\t\t\t\t\t<div class=\"hfe-nav-menu-icon\">\n\t\t\t\t\t\t<i aria-hidden=\"true\"  class=\"fas fa-align-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<nav class=\"hfe-dropdown-expandible hfe-nav-menu__layout-expandible hfe-nav-menu__submenu-arrow\" data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-right&quot;&gt;&lt;\/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;\/i&gt;\" data-full-width=\"yes\">\n\t\t\t\t\t<ul id=\"menu-1-714b078\" class=\"hfe-nav-menu\"><li id=\"menu-item-2151\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/01-menu\/\" class = \"hfe-menu-item\">CADIR : F.GHIRINGHELLI<\/a><\/li>\n<li id=\"menu-item-2152\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/02-menu\/\" class = \"hfe-menu-item\">Epi2THM : M.CALLANAN<\/a><\/li>\n<li id=\"menu-item-2672\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/03-menu\/\" class = \"hfe-menu-item\">HSP-PATHIES: C.GARRIDO<\/a><\/li>\n<li id=\"menu-item-2677\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/equipe-descartes\/\" class = \"hfe-menu-item\">DESCARTES: O. MICHEAU<\/a><\/li>\n<li id=\"menu-item-2673\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/04-menu\/\" class = \"hfe-menu-item\">EPICAD : C. LEPAGE<\/a><\/li>\n<li id=\"menu-item-986\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/www.gad-bfc.org\/\" class = \"hfe-menu-item\">GAD : C. THAUVIN<\/a><\/li>\n<li id=\"menu-item-2674\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/06-menu\/\" class = \"hfe-menu-item\">PADYS : B. VERGES<\/a><\/li>\n<li id=\"menu-item-2675\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/07-menu\/\" class = \"hfe-menu-item\">NUTOX : N. KHAN<\/a><\/li>\n<li id=\"menu-item-2676\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/08-menu\/\" class = \"hfe-menu-item\">LIPNESS : D. MASSON<\/a><\/li>\n<li id=\"menu-item-987\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/blog.u-bourgogne.fr\/yalcingroup\/\" class = \"hfe-menu-item\">B. YALCIN<\/a><\/li>\n<\/ul> \n\t\t\t\t<\/nav>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc023d3 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"bc023d3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1dce508\" data-id=\"1dce508\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72afc37 elementor-widget elementor-widget-heading\" data-id=\"72afc37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Physiopathologie des Dyslipid\u00e9mies\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1e97b8 elementor-widget elementor-widget-text-editor\" data-id=\"c1e97b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En effet les personnes pr\u00e9sentant un diab\u00e8te et\/ou une insulino-r\u00e9sistance (syndrome m\u00e9tabolique) pr\u00e9sentent un risque cardiovasculaire tr\u00e8s nettement augment\u00e9 qui est largement favoris\u00e9 par les anomalies lipidiques ath\u00e9rog\u00e8nes observ\u00e9es dans ces situations cliniques.Notre but de recherche et de mieux comprendre la physiopathologie de la dyslipid\u00e9mie associ\u00e9e au diab\u00e8te et \u00e0 la r\u00e9sistance \u00e0 l&rsquo;insuline afin d&rsquo;individualiser de nouvelles cibles th\u00e9rapeutiques pour pr\u00e9venir le risque cardiovasculaire associ\u00e9 au diab\u00e8te et \u00e0 l&rsquo;insulino-r\u00e9sistance. Depuis plusieurs ann\u00e9es, notre \u00e9quipe a su d\u00e9velopper une recherche translationnelle reconnue. Il faut signaler que notre \u00e9quipe comporte plusieurs m\u00e9decins largement investis dans la recherche clinique et translationnelle avec un acc\u00e8s facile \u00e0 des patients en vue de recherche humaine in vivo.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-463dd40 elementor-widget elementor-widget-heading\" data-id=\"463dd40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Notre activit\u00e9 de recherche se d\u00e9cline autour des trois axes suivants :\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78dbfd0 elementor-widget elementor-widget-text-editor\" data-id=\"78dbfd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b> 1) \u00c9tude des anomalies du m\u00e9tabolisme lipidique au cours du diab\u00e8te et de l&rsquo;insulino-r\u00e9sistance (incluant des \u00e9tudes cin\u00e9tiques des lipoprot\u00e9ines, in vivo, chez l\u2019Homme). <\/b><\/p><p><b> 2) Etude des HDL au cours du diab\u00e8te et de l&rsquo;insulino-r\u00e9sistance <\/b><\/p><p><b> 3) Implication du syst\u00e8me endocannabino\u00efde dans le diab\u00e8te et l&rsquo;insulino-r\u00e9sistance <\/b><\/p><p>Les principaux r\u00e9sultats obtenus, pour chaque axe, au cours de la p\u00e9riode 2016 2021 sont indiqu\u00e9s ci-dessous :<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d5625a0 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d5625a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-410bd85\" data-id=\"410bd85\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3bac779 elementor-widget elementor-widget-heading\" data-id=\"3bac779\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Nos th\u00e9matiques de recherche :\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672c02b elementor-widget elementor-widget-accordion\" data-id=\"672c02b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1081\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1081\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">\u00c9tude des anomalies du m\u00e9tabolisme lipidique au cours du diab\u00e8te et de l'insulino-r\u00e9sistance <\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1081\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1081\"><div id=\"collapseOne\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><div id=\"1\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p>\u2022 D\u00e9monstration d&rsquo;une relation \u00e9troite entre le catabolisme de l\u2019apoA-II des HDL et le catabolisme des VLDL1 dans le syndrome m\u00e9tabolique (J Clin Endocrinol Metab 2016).<\/p><p>\u2022 D\u00e9monstration que l&rsquo;agoniste GLP-1, liraglutide, r\u00e9duit l\u2019hyperlipid\u00e9mie postprandiale, chez les patients diab\u00e9tiques de type 2, par deux effets: r\u00e9duction de la production de l\u2019apoB48 et acc\u00e9l\u00e9ration du catabolisme de l\u2019apoB48 et , par ailleurs, que le liraglutide a un effet direct en r\u00e9duisant l&rsquo;expression des g\u00e8nes impliqu\u00e9s dans la production des chylomicrons (Arteriosclerosis, Thrombosis, and Vascular Biology 2018).<\/p><p>\u2022 D\u00e9monstration que l&rsquo;agonisteGLP-1, liraglutide, acc\u00e9l\u00e8re le catabolisme des lipoprot\u00e9ines contenant l\u2019apoB100, au cours du diab\u00e8te de type 2, et qu&rsquo;il r\u00e9duit l&rsquo;expression de la Proprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) (Diabetes Care 2021).<\/p><p>\u2022 D\u00e9monstration, dans une \u00e9tude multicentrique, d&rsquo;une alt\u00e9ration de la synth\u00e8se de novo du glutathion au cours de la st\u00e9atose (Molecular Systems Biology 2017).<\/p><p>\u2022 D\u00e9monstration, chez les patients diab\u00e9tiques de type 2, d&rsquo;une r\u00e9duction moyenne de 33% du contenu en graisse h\u00e9patique apr\u00e8s six mois de traitement par l&rsquo;agonisteGLP-1, liraglutide, et analyse montrant que cet effet est principalement li\u00e9 \u00e0 la r\u00e9duction pond\u00e9rale observ\u00e9e sous traitement (J Clin Endocrinol Metab. 2017).<\/p><p>\u2022 D\u00e9monstration que le risque de cancer h\u00e9patique, chez les patients atteints de cirrhose, est associ\u00e9e \u00e0 un niveau plus \u00e9lev\u00e9 d&rsquo;acide gras linol\u00e9ique et eicosadieno\u00efque et un niveau plus faible d&rsquo;acides gras arachidonique et st\u00e9arique dans la membrane des \u00e9rythrocytes (Alimentary Pharmacology &amp; Therapeutics 2020).<\/p><\/div><\/div><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1082\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1082\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">\u00c9tude des HDL au cours du diab\u00e8te et de l'insulino-r\u00e9sistance <\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1082\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1082\"><div id=\"2\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p>\u2022 Modification significative du phingophospholipidome des HDL chez les sujets ob\u00e8ses non diab\u00e9tiques avec syndrome m\u00e9tabolique : D\u00e9pl\u00e9tion en sphingosine-1-phosphate, sphingomy\u00e9lines et certains plasmalog\u00e8nes (Atherosclerosis 2016).<\/p><p>\u2022 D\u00e9monstration que la d\u00e9pl\u00e9tion en sphingosine-1-phosphate est responsable d&rsquo;une r\u00e9duction de l&rsquo;activation, par les HDL, de la NO synthase endoth\u00e9liale (Arteriosclerosis, Thrombosis, and Vascular Biology 2017).<\/p><p>\u2022 D\u00e9monstration que les traitements par glucocortico\u00efdes, bien qu&rsquo;ils augmentent le taux plasmatique de HDL cholest\u00e9rol, r\u00e9duisent significativement l&rsquo;effet des HDL sur l\u2019efflux du cholest\u00e9rol (European Journal of Endocrinology 2020).<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1083\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1083\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> Implication du syst\u00e8me endocannabino\u00efde dans le diab\u00e8te et l'insulino-r\u00e9sistance<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1083\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1083\"><div id=\"3\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p>\u2022 D\u00e9monstration que l&rsquo;apport pr\u00e9coce d&rsquo;acide gras om\u00e9ga3, chez l&rsquo;animal, r\u00e9duit le niveau d&rsquo;expression du syst\u00e8me endocannabino\u00efde dans les tissus p\u00e9riph\u00e9riques et pr\u00e9vient, \u00e0 l&rsquo;\u00e2ge adulte, la survenue d&rsquo;anomalies m\u00e9taboliques induites par un r\u00e9gime riche en graisse (Diabetes 2016).<\/p><p>\u2022 D\u00e9monstration que l&rsquo;activation du syst\u00e8me endocannabino\u00efde p\u00e9riph\u00e9rique r\u00e9duit l&rsquo;effet inhibiteur de l&rsquo;insuline sur la lipase hormono-sensible du tissu adipeux (American Journal of Physiology. Endocrinology and Metabolism 2017).<\/p><p>\u2022 D\u00e9monstration que l&rsquo;activation du r\u00e9cepteur aux endocannabino\u00efdes, CB1R, dans les podocytes contribue \u00e0 la dysfonction glom\u00e9rulaire et tubulaire au cours de la n\u00e9phropathie diab\u00e9tique (Diabetes, Obesity &amp; Metabolism 2018).<\/p><p>\u2022 Preuve que l&rsquo;inhibition du r\u00e9cepteur aux endocannabino\u00efdes, CB1R, r\u00e9duit directement la production h\u00e9patique des VLDL et que l&rsquo;inhibition de l&rsquo;oxyde nitrique synthase inductible (iNOS) r\u00e9duit l&rsquo;expression de la proprotein convertase subtilisin\/kexin type 9 (PCSK9) via un m\u00e9canisme d\u00e9pendant de mTORC1 (Diabetes 2020).<\/p><p>\u2022 D\u00e9monstration que les endocannabino\u00efdes produits dans le tissu adipeux blanc modulent la lipolyse chez les animaux et humains de poids normal mais non chez les ob\u00e8ses, \u00e0 l\u2019\u00e9tat \u00e0 jeun (Frontiers in Endocrinology 2021).<\/p><p>\u2022 D\u00e9veloppement d&rsquo;un antagoniste sp\u00e9cifique du r\u00e9cepteur p\u00e9riph\u00e9rique aux endocannabino\u00efdes, CB1R, pour lequel un brevet a \u00e9t\u00e9 d\u00e9pos\u00e9 en 2017 (FR3041641N\u00b0 1559067) avec une extension pour le Canada (2999617) et les \u00c9tats-Unis en 2018 (US 20180265498 A1).<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Retour PADYS : T. JOURDAN Menu CADIR : F.GHIRINGHELLI Epi2THM : M.CALLANAN HSP-PATHIES: C.GARRIDO DESCARTES: O. MICHEAU EPICAD : C. LEPAGE GAD : C. THAUVIN PADYS : B. VERGES NUTOX : N. KHAN LIPNESS : D. MASSON B. YALCIN Physiopathologie des Dyslipid\u00e9mies En effet les personnes pr\u00e9sentant un diab\u00e8te et\/ou une insulino-r\u00e9sistance (syndrome m\u00e9tabolique) pr\u00e9sentent &#8230; <a title=\"06-Theme\" class=\"read-more\" href=\"https:\/\/ctm.ube.fr\/index.php\/06-theme\/\" aria-label=\"En savoir plus sur 06-Theme\">Lire la suite<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-2395","page","type-page","status-publish"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.5 - aioseo.com -->\n\t<meta name=\"description\" content=\"Retour Retour PADYS : T. 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