{"id":2477,"date":"2023-08-31T11:55:55","date_gmt":"2023-08-31T11:55:55","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=2477"},"modified":"2023-09-11T07:41:07","modified_gmt":"2023-09-11T07:41:07","slug":"08-theme","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/08-theme\/","title":{"rendered":"08-Theme"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2477\" class=\"elementor elementor-2477\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca9e50e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca9e50e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"make-column-clickable-elementor elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-fc34845\" data-column-clickable=\"https:\/\/ctmtest2.fr\/01-menu\/\" data-column-clickable-blank=\"_self\" data-id=\"fc34845\" data-element_type=\"column\" data-e-type=\"column\"><a href=\"https:\/\/ctmtest2.fr\/01-menu\/\" class=\"make-column-clickable-link\"><span class=\"make-column-clickable-text\">Retour<\/span><\/a>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-634f7aa elementor-widget elementor-widget-button\" data-id=\"634f7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/08-menu\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Retour<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-253fdf7\" data-id=\"253fdf7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6e39dc elementor-widget elementor-widget-heading\" data-id=\"a6e39dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-xl\">LIPNESS : D. Masson<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20e3194 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"20e3194\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b806867\" data-id=\"b806867\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-714b078 hfe-menu-item-flex-end hfe-submenu-icon-arrow hfe-link-redirect-child elementor-widget elementor-widget-navigation-menu\" data-id=\"714b078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;hamburger_menu_align&quot;:&quot;flex-end&quot;,&quot;padding_horizontal_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;hamburger_align&quot;:&quot;center&quot;,&quot;dropdown_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;padding_horizontal_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_horizontal_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"navigation-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"hfe-nav-menu hfe-layout-expandible hfe-nav-menu-layout expandible\" data-layout=\"expandible\">\n\t\t\t\t<div role=\"button\" class=\"hfe-nav-menu__toggle elementor-clickable\" tabindex=\"0\" aria-label=\"Basculer le menu\">\n\t\t\t\t\t<span class=\"screen-reader-text\">Menu<\/span>\n\t\t\t\t\t<div class=\"hfe-nav-menu-icon\">\n\t\t\t\t\t\t<i aria-hidden=\"true\"  class=\"fas fa-align-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<nav class=\"hfe-dropdown-expandible hfe-nav-menu__layout-expandible hfe-nav-menu__submenu-arrow\" data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-right&quot;&gt;&lt;\/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;\/i&gt;\" data-full-width=\"yes\">\n\t\t\t\t\t<ul id=\"menu-1-714b078\" class=\"hfe-nav-menu\"><li id=\"menu-item-2151\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/01-menu\/\" class = \"hfe-menu-item\">CADIR : F.GHIRINGHELLI<\/a><\/li>\n<li id=\"menu-item-2152\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/02-menu\/\" class = \"hfe-menu-item\">Epi2THM : M.CALLANAN<\/a><\/li>\n<li id=\"menu-item-2672\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/03-menu\/\" class = \"hfe-menu-item\">HSP-PATHIES: C.GARRIDO<\/a><\/li>\n<li id=\"menu-item-2677\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/equipe-descartes\/\" class = \"hfe-menu-item\">DESCARTES: O. MICHEAU<\/a><\/li>\n<li id=\"menu-item-2673\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/04-menu\/\" class = \"hfe-menu-item\">EPICAD : C. LEPAGE<\/a><\/li>\n<li id=\"menu-item-986\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/www.gad-bfc.org\/\" class = \"hfe-menu-item\">GAD : C. THAUVIN<\/a><\/li>\n<li id=\"menu-item-2674\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/06-menu\/\" class = \"hfe-menu-item\">PADYS : B. VERGES<\/a><\/li>\n<li id=\"menu-item-2675\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/07-menu\/\" class = \"hfe-menu-item\">NUTOX : N. KHAN<\/a><\/li>\n<li id=\"menu-item-2676\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/08-menu\/\" class = \"hfe-menu-item\">LIPNESS : D. MASSON<\/a><\/li>\n<li id=\"menu-item-987\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/blog.u-bourgogne.fr\/yalcingroup\/\" class = \"hfe-menu-item\">B. YALCIN<\/a><\/li>\n<\/ul> \n\t\t\t\t<\/nav>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d5625a0 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d5625a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-410bd85\" data-id=\"410bd85\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3bac779 elementor-widget elementor-widget-heading\" data-id=\"3bac779\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Nos th\u00e9matiques de recherche :\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672c02b elementor-widget elementor-widget-accordion\" data-id=\"672c02b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1081\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1081\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> Exploration du r\u00f4le des lipoprot\u00e9ines dans la voie de transport reverse des lipopolysaccharides (RLT)<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1081\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1081\"><div id=\"collapseOne\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><b>Chercheurs principaux:<\/b><\/p><ul><li>Laurent Lagrost<\/li><li>Val\u00e9rie Deckert<\/li><li>Thomas Gautier<\/li><li>Maxime Nguyen<\/li><\/ul><p>Les lipopolysaccharides (LPS) se lient et activent le r\u00e9cepteur TLR4 \u00e0 la surface des cellules immunitaires, conduisant \u00e0 la lib\u00e9ration de cytokines pro-inflammatoires et \u00e0 l&rsquo;inflammation. Alternativement, les blebs bact\u00e9riens formant de larges agr\u00e9gats de LPS peuvent \u00eatre d\u00e9grad\u00e9s via notamment le transfert de mol\u00e9cules de LPS vers les lipoprot\u00e9ines. Ce processus entra\u00eene la neutralisation du LPS et son \u00e9limination vers le foie. Des observations r\u00e9centes sugg\u00e8rent que la PLTP et la CETP, en tant que membres de la famille des prot\u00e9ines de transfert de lipides et des lipopolysaccharides, jouent un r\u00f4le moteur dans le RLT, modulant ainsi l&rsquo;inflammation et l&rsquo;immunit\u00e9 inn\u00e9e.<\/p><p>Publications r\u00e9centes :<\/p><ul><li>Deckert V, Lemaire S, Ripoll P-J, de Barros J-PP, Labb\u00e9 J, Borgne CC-L, Turquois V, Maquart G, Larose D, Desroche N, M\u00e9n\u00e9trier F, Le Guern N, Lebrun LJ, Desrumaux C, Gautier T, Grober J, Thomas C, Masson D, Houdebine L-M, Lagrost L. Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis. Sci Rep. 2017;7:3053.<\/li><li>Sali W, Patoli D, Pais de Barros J-P, Labb\u00e9 J, Deckert V, Duh\u00e9ron V, Le Guern N, Blache D, Chaumont D, Lesniewska E, Gasquet B, Paul C, Moreau M, Denat F, Masson D, Lagrost L, Gautier T. Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo. Front Microbiol. 2019;10:1774.<\/li><li>Nguyen M, Pallot G, Jalil A, Tavernier A, Dusuel A, Le Guern N, Lagrost L, Pais de Barros J-P, Choubley H, Bergas V, Guinot P-G, Masson D, Bouhemad B, Gautier T. Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein. Front Immunol. 2021;12:622935.<\/li><\/ul><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1082\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1082\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">  R\u00f4le des acides biliaires dans la neutralisation \/ d\u00e9toxification du LPS<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1082\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1082\"><div id=\"2\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><b>Chercheurs principaux :<\/b><\/p><ul><li>St\u00e9phane Mandard<\/li><li>Thomas Gautier<\/li><\/ul><p>Les mol\u00e9cules de LPS sont \u00e9limin\u00e9es de l\u2019organisme par excr\u00e9tion biliaire lors de l\u2019\u00e9tape finale de la voie de transport inverse du LPS. Alors que certains travaux ant\u00e9rieurs ont document\u00e9 l&rsquo;interaction biophysique des endotoxines avec des acides biliaires purifi\u00e9s, les cons\u00e9quences physiopathologiques de cette interaction en termes de capacit\u00e9 pro-inflammatoire et de nutralisation du LPS ne sont pas compl\u00e9tement \u00e9lucid\u00e9es. Nous visons \u00e0 mieux comprendre le lien entre le m\u00e9tabolisme des acides biliaires et la neutralisation \/ d\u00e9toxification du LPS.<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1083\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1083\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> Etudes de l\u2019endotox\u00e9mie dans diff\u00e9rentes populations humaines et cons\u00e9quences physiopathologiques dans la septic\u00e9mie et le choc septique<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1083\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1083\"><p><b>Chercheurs principaux :<\/b><\/p><ul><li>Jean-Pierre Quenot<\/li><li>Belaid Bouhemad<\/li><li>Laurent Lagrost<\/li><\/ul><p>L&rsquo;incidence des septic\u00e9mies s\u00e9v\u00e8res et des chocs septiques au seins des unit\u00e9s de soins intensifs est d\u2019environ 15% et la mortalit\u00e9 hospitali\u00e8re associ\u00e9es est de 25% et 49%, respectivement. Malgr\u00e9 des avanc\u00e9es significatives dans notre compr\u00e9hension de la physiopathologie de la septic\u00e9mie s\u00e9v\u00e8re et du choc septique, les tentatives de traduire ces r\u00e9sultats par de nouveaux traitements et par une am\u00e9lioration du pronostic des patients restent d\u00e9cevantes. L&rsquo;un des principaux objectifs de l&rsquo;\u00e9quipe Lipness est de d\u00e9terminer dans quelle mesure la neutralisation et l&rsquo;\u00e9limination du LPS pourrait constituer une nouvelle approche pertinente pour am\u00e9liorer le pronostic clinique du choc septique.<\/p><p>Publication R\u00e9centes:<\/p><ul><li>Dargent A, Pais De Barros J-P, Ksiazek E, Fournel I, Dusuel A, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot J-P. Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study. Intensive Care Med. 2019;45:1678\u20131680.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1084\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1084\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">  R\u00f4le du GLP-1 et de l'insuline dans la r\u00e9ponse inflammatoire m\u00e9di\u00e9e par le LPS<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1084\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1084\"><p><b>Investigateur principal :<\/b><\/p><ul><li>Jacques Grober<\/li><\/ul><p>Chez des sujets sains, une endotox\u00e9mie mod\u00e9r\u00e9e a \u00e9t\u00e9 associ\u00e9e, \u00e0 court terme, \u00e0 une sensibilit\u00e9 accrue \u00e0 l&rsquo;insuline tandis qu&rsquo;une r\u00e9sistance \u00e0 l&rsquo;insuline peut survenir \u00e0 de mani\u00e8re plus tardive. Nous avons r\u00e9cemment montr\u00e9 que le LPS est capable d&rsquo;augmenter les niveaux circulants de Glucagon Like Peptide-1 (GLP-1), une incr\u00e9tine impliqu\u00e9e dans la s\u00e9cr\u00e9tion d&rsquo;insuline stimul\u00e9e par le glucose (GSIS).<\/p><p>Publication r\u00e9cente :<\/p><ul><li>Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros J-P, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J. Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion. Cell Rep. 2017;21:1160\u20131168.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1085\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1085\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">  Modulation du m\u00e9tabolisme des acides gras dans les macrophages et inflammation<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1085\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1085\"><p><b>Chercheurs principaux :<\/b><\/p><ul><li>David Masson<\/li><li>Charles Thomas<\/li><\/ul><p>Les phospholipides sont continuellement remodel\u00e9s par d\u00e9acylation et r\u00e9acylation du fait des actions oppos\u00e9es des phospholipases A2 et des lysophospholipides acyl-transf\u00e9rases (LPLAT). Les LPLAT affectent \u00e0 la fois la teneur en acides gras polyinsatur\u00e9s des phospholipides et la disponibilit\u00e9 des acides gras libres tels que l&rsquo;acide arachidonique utilis\u00e9 pour la synth\u00e8se des eicosano\u00efdes. En utilisant des mod\u00e8les de souris sp\u00e9cifiques et des \u00e9chantillons de patients humains, nous \u00e9valuons l&rsquo;impact du m\u00e9tabolisme des phospholipides et des acides gras dans les cellules my\u00e9lo\u00efdes sur le d\u00e9veloppement de l&rsquo;inflammation et de l&rsquo;ath\u00e9roscl\u00e9rose.<\/p><p>Publications R\u00e9centes:<\/p><ul><li>M\u00e9n\u00e9gaut L, Jalil A, Thomas C, Masson D. Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs. Atherosclerosis. 2019;291:52\u201361.<\/li><li>M\u00e9n\u00e9gaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Goff WL, Mathew MJ, R\u00e9b\u00e9 C, D\u00e9rang\u00e8re V, Laubriet A, Crespy V, Barros J-PP de, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D. Interplay between Liver X Receptor and Hypoxia Inducible Factor 1\u03b1 Potentiates Interleukin-1\u03b2 Production in Human Macrophages. Cell Reports [Internet]. 2020 [cited 2020 May 19];31. Available from: https:\/\/www.cell.com\/cell-reports\/abstract\/S2211-1247(20)30618-5<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1086\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-1086\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">  R\u00e9ponse mitophagie et inflammatoire<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1086\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-1086\"><p><b>Chercheurs principaux :<\/b><\/p><ul><li>Charles Thomas<\/li><li>Pierre Emmanuel Charles<\/li><li>Mathieu Blot<\/li><\/ul><p>La mitophagie est une autophagie d\u00e9di\u00e9e aux mitochondries permettant l&rsquo;\u00e9limination des mitochondries endommag\u00e9es dans les cellules. Nos recherches visent \u00e0 identifier la voie de signalisation r\u00e9sultant de l&rsquo;inhibition de la mitophagie par le LPS et l&rsquo;IFN\u03b3 dans les macrophages. Nous \u00e9tudions si cette inhibition de la mitophagie se produit dans les macrophages et les neutrophiles polynucl\u00e9aires dans le contexte d&rsquo;infections bact\u00e9riennes telles que les septic\u00e9mies ou des mod\u00e8les exp\u00e9rimentaux de pneumonie et nous explorons si la modulation de la mitophagie peut affecter les r\u00e9ponses inflammatoires et bact\u00e9ricides.<\/p><p>Publications R\u00e9centes :<\/p><ul><li>Patoli D, Mignotte F, Deckert V, Dusuel A, Dumont A, Rieu A, Jalil A, Van Dongen K, Bourgeois T, Gautier T, Magnani C, Le Guern N, Mandard S, Bastin J, Djouadi F, Schaeffer C, Guillaumot N, Narce M, Nguyen M, Guy J, Dargent A, Quenot J-P, Rialland M, Masson D, Auwerx J, Lagrost L, Thomas C. Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis. J Clin Invest. 2020<\/li><li>Blot M, Jacquier M, Pauchard L-A, Rebaud C, Marlin C, Hamelle C, Bataille A, Croisier D, Thomas C, Jalil A, Mirfendereski H, Piroth L, Chavanet P, Bensoussan D, Laroye C, Reppel L, Charles P-E. Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits. Anesthesiology. 2022;136:293\u2013313.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1087\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-1087\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">  Acides gras polyinsatur\u00e9s et inflammation: comprendre le r\u00f4le des AGPI dans le contexte de l'ob\u00e9sit\u00e9<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1087\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-1087\"><p><b>Chercheurs principaux :<\/b><\/p><ul><li>J\u00e9rome Bellenger<\/li><li>Sandrine Bellenger<\/li><li>Michel Narce<\/li><\/ul><p>Les acides gras N-3 sont connus pour limiter le d\u00e9veloppement de l&rsquo;ob\u00e9sit\u00e9, mais les m\u00e9canismes mol\u00e9culaires ne sont pas enti\u00e8rement \u00e9lucid\u00e9s. Une diminution du rapport n-6 \/ n-3 via des r\u00e9gimes enrichis en acides gras n-3 peut exercer des effets b\u00e9n\u00e9fiques sur l\u2019ob\u00e9sit\u00e9 et la r\u00e9sistance \u00e0 l&rsquo;insuline dans des mod\u00e8les de rongeurs. Nos objectifs sont de d\u00e9terminer si une teneur \u00e9lev\u00e9e en acides gras n-3 peut prot\u00e9ger contre l&rsquo;ob\u00e9sit\u00e9 alimentaire en att\u00e9nuant l&rsquo;endotox\u00e9mie m\u00e9tabolique et de d\u00e9chiffrer les m\u00e9canismes mol\u00e9culaires impliqu\u00e9s<\/p><p>Publication R\u00e9cente :<\/p><ul><li>Bidu C, Escoula Q, Bellenger S, Spor A, Galan M, Geissler A, Bouchot A, Dardevet D, Morio B, Cani PD, Lagrost L, Narce M, Bellenger J. The Transplantation of \u03c93 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders. Diabetes. 2018;67:1512\u20131523.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Retour LIPNESS : D. Masson Menu CADIR : F.GHIRINGHELLI SAPHIHR : M.CALLANAN GAD : C. THAUVIN B. YALCIN LIIC A. BETTAIEB Nos th\u00e9matiques de recherche : Exploration du r\u00f4le des lipoprot\u00e9ines dans la voie de transport reverse des lipopolysaccharides (RLT) Chercheurs principaux: Laurent Lagrost Val\u00e9rie Deckert Thomas Gautier Maxime Nguyen Les lipopolysaccharides (LPS) se lient &#8230; <a title=\"08-Theme\" class=\"read-more\" href=\"https:\/\/ctm.ube.fr\/index.php\/08-theme\/\" aria-label=\"En savoir plus sur 08-Theme\">Lire la suite<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-2477","page","type-page","status-publish"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.5 - aioseo.com -->\n\t<meta name=\"description\" content=\"Retour Retour LIPNESS : D. Masson Menu CADIR : F.GHIRINGHELLI Epi2THM : M.CALLANAN HSP-PATHIES: C.GARRIDO DESCARTES: O. MICHEAU EPICAD : C. LEPAGE GAD : C. 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