{"id":2659,"date":"2023-09-08T08:50:28","date_gmt":"2023-09-08T08:50:28","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=2659"},"modified":"2023-09-08T11:57:38","modified_gmt":"2023-09-08T11:57:38","slug":"01-theme-anglais","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/","title":{"rendered":"01-Theme &#8211; Anglais"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2659\" class=\"elementor elementor-2659\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca9e50e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca9e50e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"make-column-clickable-elementor elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-fc34845\" data-column-clickable=\"https:\/\/ctmtest2.fr\/01-menu\/\" data-column-clickable-blank=\"_self\" data-id=\"fc34845\" data-element_type=\"column\" data-e-type=\"column\"><a href=\"https:\/\/ctmtest2.fr\/01-menu\/\" class=\"make-column-clickable-link\"><span class=\"make-column-clickable-text\">Back<\/span><\/a>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-634f7aa elementor-widget elementor-widget-button\" data-id=\"634f7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/01-menu-anglais\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Back<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-253fdf7\" data-id=\"253fdf7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6e39dc elementor-widget elementor-widget-heading\" data-id=\"a6e39dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">CADIR : F. GHIRINGHELLI<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20e3194 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"20e3194\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b806867\" data-id=\"b806867\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-714b078 hfe-menu-item-flex-end hfe-submenu-icon-arrow hfe-link-redirect-child elementor-widget elementor-widget-navigation-menu\" data-id=\"714b078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;hamburger_menu_align&quot;:&quot;flex-end&quot;,&quot;padding_horizontal_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;hamburger_align&quot;:&quot;center&quot;,&quot;dropdown_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;padding_horizontal_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_horizontal_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"navigation-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"hfe-nav-menu hfe-layout-expandible hfe-nav-menu-layout expandible\" data-layout=\"expandible\">\n\t\t\t\t<div role=\"button\" class=\"hfe-nav-menu__toggle elementor-clickable\" tabindex=\"0\" aria-label=\"Basculer le menu\">\n\t\t\t\t\t<span class=\"screen-reader-text\">Menu<\/span>\n\t\t\t\t\t<div class=\"hfe-nav-menu-icon\">\n\t\t\t\t\t\t<i aria-hidden=\"true\"  class=\"fas fa-align-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<nav class=\"hfe-dropdown-expandible hfe-nav-menu__layout-expandible hfe-nav-menu__submenu-arrow\" data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-right&quot;&gt;&lt;\/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;\/i&gt;\" data-full-width=\"yes\">\n\t\t\t\t\t<ul id=\"menu-1-714b078\" class=\"hfe-nav-menu\"><li id=\"menu-item-2693\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/01-menu-anglais\/\" class = \"hfe-menu-item\">CADIR : F. Ghiringhelli<\/a><\/li>\n<li id=\"menu-item-2962\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/02-menu-anglais\/\" class = \"hfe-menu-item\">Epi2THM : M. Callanan<\/a><\/li>\n<li id=\"menu-item-2963\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/03-menu-anglais\/\" class = \"hfe-menu-item\">HSP-PATHIES : C. Garrido<\/a><\/li>\n<li id=\"menu-item-2961\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/descartes_team\/\" class = \"hfe-menu-item\">DESCARTES : O. Micheau<\/a><\/li>\n<li id=\"menu-item-2964\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/04-menu-anglais\/\" class = \"hfe-menu-item\">EPICAD : C. Lepage<\/a><\/li>\n<li id=\"menu-item-2967\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/www.gad-bfc.org\/\" class = \"hfe-menu-item\">GAD : C. Thauvin<\/a><\/li>\n<li id=\"menu-item-2965\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/06-menu-anglais\/\" class = \"hfe-menu-item\">PADYS : B. Verg\u00e8s<\/a><\/li>\n<li id=\"menu-item-2966\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/07-menu-anglais\/\" class = \"hfe-menu-item\">NUTOX : N. Kahn<\/a><\/li>\n<li id=\"menu-item-2960\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/08-menu-anglais\/\" class = \"hfe-menu-item\">LIPNESS : D. Masson<\/a><\/li>\n<li id=\"menu-item-2968\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/blog.u-bourgogne.fr\/yalcingroup\/\" class = \"hfe-menu-item\">B. Yalcin<\/a><\/li>\n<\/ul> \n\t\t\t\t<\/nav>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d5625a0 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d5625a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-410bd85\" data-id=\"410bd85\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f135aee elementor-widget elementor-widget-heading\" data-id=\"f135aee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Therapies and Immune REsponse in CancerS : TIRECS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04fbbd6 elementor-widget elementor-widget-text-editor\" data-id=\"04fbbd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tumors are frequently characterized by the presence of an inflammatory environment and the presence of an immune cell infiltrate. Our research team focuses on the relationships between cancer cells, inflammation and intratumoral immune response. We develop biomarker strategies, and more fundamental aspect of tumor immunology by studying CD8 adaptive T cells responses, CD4 T cells responses and innate lymphoid cells in the context of cancer therapies. We are also studying the impact of fatty acids and of chemotherapeutic treatments on immune and cancer cells. A better understanding of these mechanisms will ultimately result in improved therapeutic strategies against cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bac779 elementor-widget elementor-widget-heading\" data-id=\"3bac779\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our research themes :\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672c02b elementor-widget elementor-widget-accordion\" data-id=\"672c02b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1081\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1081\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">CD8 and Immunomodulation<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1081\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1081\"><div id=\"1\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><b>Team involved in this project :<\/b><\/p><ul><li>Ghiringhelli Fran\u00e7ois (PU-PH) Contact : <a href=\"mailto:&quot;fghiringhelli@cgfl.fr&quot;\">fghiringhelli@cgfl.fr<\/a><\/li><li>Sylvain Ladoire, (PU-PH, HDR)<\/li><li>Fanny Chalmin (PhD)<\/li><li>Emeric Limagne (PhD)<\/li><li>C\u00e9dric R\u00e9b\u00e9 (PhD, HDR)<\/li><li>Marion Thibaudin (PhD)<\/li><li>Laura Kalfeist (PhD Student)<\/li><li>Ana\u00efs Perrichet (PhD Student)<\/li><li>Susy Daumoine (TR)<\/li><li>L\u00e9a Hampe (TR)<\/li><li>Alis Ili\u00e9 (TR)<\/li><li>Lisa Nuttin (TR)<\/li><\/ul><p>It has been recently shown that the immune system can make a decisive contribution to the therapeutic efficacy of conventional anticancer immune therapies (chemotherapy and radiotherapy). Our goal is to design chemo-immunotherapeutic protocols tailored to every patient.<\/p><p>We foster our interest on NSCLC, digestive cancer and breast cancer. Our strategy is to modelize human treatment with chemoimmunotherapy or targeted therapies plus immunotherapy in preclinical animal models. We design models of resistant to classical treatment to first explain the mechanisms of resistance and thus to develop innovative strategies to circumscribe immunoresistance.<\/p><p>We currently address the role of fibroblast and TGF beta in immunoresistance in breast cancer, the role of IL1 in the efficacy of chemoimmunotherapies in Lung and digestive cancers, the role of MAPK pathway in immunoresistance in lung cancer and finally we decipher the role of CD4 T cells in their capacity to tune efficacy of checkpoint inhibitors.<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1082\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1082\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> Histology<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1082\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1082\"><div id=\"2\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><b>Team involved in this project :<\/b><ul><li>Caroline Truntzer (PhD)<\/li><li>Valentin Derang\u00e8re (MCU PH)<\/li><li>David Rageot (TR)<\/li><\/ul><p><b> Image analysis:<\/b><\/p><p>We have skills to develop scripts mainly dedicated to brightfield image analysis such as standard staining (HE, trichrome) or immunohistochemistry staining (DAB or AEC chromogens) on large or small cohort. We are also able to edit AI models to classify tissue through a whole slide image using machine learning or deep learning strategy. Features extracted from image can also be linked to clinical data to evaluate patients&rsquo; prognosis for instance.<\/p><p><img decoding=\"async\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/Histology_pastedImage.jpg\" alt=\"\" \/><\/p><p><b> Next Generation Sequencing data analysis:<\/b><\/p><p>We provide skills for the analysis of sequencing data, including single-cell RNAseq, RNAseq and Whole Exome (WES) data. Raw data are processed through adapted bioinformatics pipelines and statistical analysis dedicated to high dimensional setting are then used to link these data with clinical variables of interest.<\/p><p><img decoding=\"async\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/Histology_index.jpg\" alt=\"\" \/><\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1083\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1083\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Cancer and Fatty Acid<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1083\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1083\"><div id=\"3\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><b>Team involved in this project :<\/b><\/p><ul><li>Micka\u00ebl Rialland (MCU, HDR)<\/li><li>Jean-Louis Connat (Professeur \u00e9m\u00e9rite)<\/li><li>Sabrina Perrey (Technicienne)<\/li><li>Alois Dusuel (Ing\u00e9nieur d&rsquo;\u00e9tude)<\/li><li>Trinh-Le-Vi Kieu (Ing\u00e9nieur d&rsquo;\u00e9tude Labex LipiSTIC)<\/li><li>Emma Groetz (PhD)<\/li><li>L\u00e9a Pierre (PhD)<\/li><\/ul><p>Metabolism reprogramming is a hallmark of cancers and one aproach to kill cancer cells is to interfere with the metabolic rewiring. We are interested in understanding the role of fatty acid reprogramming in cancer cells and their heterotypic interactions with immune cells. Moreover, we evaluate the effect of dietary lipids on cancer progression and metabolism regulation.<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1084\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1084\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">\u201cLymphoid cells in cancer\u201d, LyCCa group<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1084\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1084\"><div id=\"4\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><strong>Team involved in this project\u00a0:<\/strong><u> <\/u><\/p><b>Permanent Researchers : <\/b><ul type=\"disc\"><li style=\"list-style-type: none;\"><ul type=\"disc\"><li>VEGRAN Fr\u00e9d\u00e9rique (PhD, HDR, CR1)<\/li><li>BRUCHARD M\u00e9lanie (PhD)<\/li><\/ul><\/li><\/ul><b>Non-Permanent Researchers : <\/b><ul type=\"disc\"><li>SADISSOU Ibrahim (PhD \u2013 Post-doc)<\/li><li>HIBOS Christophe (PhD)<\/li><li>GEINDREAU Mannon (PhD)<\/li><\/ul><p>Lymphoid cell family is made up of innate and adaptive immune populations. <br \/>During the establishment of a tumor, the cells from the immune system lose their effectiveness. Understanding the mechanisms governing the differentiation, activation, migration and exhaustion of T lymphocytes, as well as the impact of treatments, is a required step to ultimately identify strategies for restoring the anti-tumor immune response. In this context, we direct our research towards the exploration of the non-canonical functions of NLRP3 in T lymphocytes and their impact on the tumor microenvironment and response to treatment.<\/p><p>ILCs are innate immune cells discovered in the late 2000s. Their role in the anti-tumor immune response remains to be deciphered. The second aim of our group is to understand their functions, not only in the tumor environment but also during the response to therapies. Our previous results show that ILC could act as a conductor in the establishment of a response to treatment. Thus, their study could allow the identification of new therapeutic strategies to improve the recruitment of immune cells as well as their activity.<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1085\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1085\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Bioactive Molecules and Health (BMH) research group<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1085\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1085\"><div id=\"5\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/BMH.jpg\" alt=\"\" \/><\/p><p><strong>Team involved in this project\u00a0:<\/strong><u> <\/u><\/p><p><b>Permanent Researchers : <\/b><\/p><ul type=\"disc\"><li style=\"list-style-type: none;\"><ul type=\"disc\"><li>Aires Virginie (Associate Professor)<\/li><li>Delmas Dominique (Professor, Group leader)<\/li><li>Hermetet Fran\u00e7ois (Associate Professor)<\/li><li>Dr Pierre-Benoit Pag\u00e8s<\/li><\/ul><\/li><\/ul><p>\u00a0<\/p><p><b>Non-Permanent Researchers : <\/b><\/p><ul type=\"disc\"><li style=\"list-style-type: none;\"><ul type=\"disc\"><li>Sghaier Randa (Post-Doctoral student)<\/li><li>Belhadj Sahla(Post-Doctoral student)<\/li><li>Cornebise Clarisse (PhD, 2nd year)<\/li><li>Mathey Aline (PhD, 3rd year)<\/li><li>Perus Maude (PhD, 1st year)<\/li><li>Mammar Elodie (Master\u2019s 2-degree student, AgroSup Engineering School, Dijon)<\/li><li>Miahle Aur\u00e9lie (Master\u2019s 2-degree student, Health Engineering-Pathway Design and Optimization of Health Products, Faculty of Pharmacy, Lyon)<\/li><li>Pires Vivien (Master\u2019s 2-degree student, University of Burgundy)<\/li><\/ul><\/li><\/ul><p>\u00a0<\/p><p><b>Contact: <\/b> <a href=\"mailto:&quot;\">dominique.delmas@u-bourgogne.fr<\/a><\/p><p>The \u201cBioactive Molecules and Health (BMH)\u201d research group is conducting <b>transdisciplinary translational research<\/b>, to evaluate the impact of bioactive compounds, extracts or formulations on health and on degenerative diseases (cancers, inflammatory and immune disorders, age-related pathologies), with two major axes, one fundamental and translational, the other aimed at industrial valorization:<\/p><ul><li><strong>Axis 1: Bioactive molecules &amp; lipid metabolism-early markers and mechanisms of disease progression <\/strong><\/li><\/ul><p>This research axis, initiated in 2010, is intended to be translational and is based on multidisciplinary approaches, combining both preclinical animal models and clinical research on patients with progressive pathologies (i.e. cancers) or evolving toward therapeutic failure. This work is carried out in close collaboration with different teams of the UMR1231 research center (Epidemiology of Cancers, Biochemistry, Oncology and Physiopathology of Dyslipidemia), the Clinical Investigation Center, the Hepatogastroenterology and digestive cancer Department of the University Hospital of Dijon, the Anticancer Center Georges-Fran\u00e7ois Leclerc (CGFL) of Dijon, as well as the \u201cEye and Nutrition\u201d team of the INRAE institute of Dijon. In addition, this work is integrated to the 5th axis \u201cManagement of treatment failures\u201d and to the structuring network \u201cIonizing Radiation in BIOlogie, combined therapies and Molecular Imaging-RIBIOTHIM-onco\u201d of the Canc\u00e9rop\u00f4le Grand-Est, as well as to the the LipSTIC Laboratory of Excellence, which was created in 2012 and renewed in 2017.<\/p><p><strong>The main goals of this axis are: <\/strong><\/p><ul><li>a) To identify early markers of cancer onset and progression<\/li><li>b) To identify early and predictive markers of patient response to treatments in the energetic metabolism of tumors and especially in lipid metabolism<\/li><li>c) To assess the role of the tumor microenvironment and tumor metabolism in cancer cells progression and response to therapeutic agents<\/li><li>d) To evaluate the potential use of bioactive molecules such as polyphenols or fatty acids as preventive agents and\/or therapeutic adjuvants when combined to various conventional chemotherapies, radiotherapy or immunotherapies.<\/li><\/ul><p><img decoding=\"async\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/BMH1.JPG\" alt=\"\" \/><\/p><ul><li><strong>Axis 2: Bioactive molecules &#8211; Health- Industrial valorization <\/strong><\/li><\/ul><p>With a view to identifying new drugs, our research group is studying the preventive or potential therapeutic properties of bioactive molecules or formulations, in relation to diverse pathologies (degenerative diseases such as AMD, cancers, inflammation, autoimmune diseases\u2026), with a special focus on their ability to delay the pathology onset or on their capacity to improve the sensitivity to conventional therapies. This latter is of clinical importance, since it may help in reducing treatments thresholds, toxicity and may contribute to enhance therapeutic success. This research axis, with a high valorization potential for companies, for the evaluation of xenobiotics, alicaments and natural molecules for nutritional or therapeutic purposes (Figure 2) aims to:<\/p><ul><li>1)determine the \u00ab\u00a0Health\u00a0\u00bb effects of nutraceuticals, cosmeceuticals in various in vitro and in vivo models in order to provide health claims or to produce proof of concept for the use of these molecules;<\/li><li>2)optimizing formulations (combinations of several compounds and determining synergistic, additive or antagonistic effects) and determining the safety of formulations.<\/li><li>3) to provide scientific expertise to industrialists in the fields of immunology, inflammation and the health evaluation of their bioactive compounds.<\/li><\/ul><p>d) Expertise and support in carrying out research projects are provided with the possibility of establishing research and development contracts under the research tax credit.<\/p><p><img decoding=\"async\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/BMH_Figure 2 anglais.jpg\" alt=\"\" \/><\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1086\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-1086\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Radiation-Induced Immune Response<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1086\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-1086\"><div id=\"6\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><b>Equipe :<\/b><b>Permanent Researcher :<\/b><ul><li style=\"list-style-type: none;\"><ul><li>MIRJOLET C\u00e9line (PhD, HDR)<\/li><\/ul><\/li><\/ul><b>Non-Permanent Researchers :<\/b><ul><li>LADJOHOUNLOU Riad (PhD \u2013 Post-doc)<\/li><li>BOUSTANI Jihane (3\u00e8me ann\u00e9e, PhD, MD)<\/li><\/ul><p>Radiotherapy (RT) is one of the major players in the treatment of cancer, along with surgery, chemotherapy and now immunotherapy (IT). It has many indications, alone or in combination with other treatments.<\/p><p>Historically, RT is delivered to patients in fractions\/sessions of 2-3 Gy (normofractionated regimen) making it possible to treat large volumes while limiting toxicities. Advances in radiotherapy techniques (image-guided IMRT, stereotaxy, etc.) make it possible to deliver high doses per fraction (hypofractionation of up to 20 Gy per fraction) by minimizing the organs at risk near the tumor and thus limiting radiation-induced toxicities.<\/p><p>Radiotherapy has a direct action on the survival of tumor cells but also on the immune system. Depending on the RT administration conditions (fractionation scheme, particles used, irradiated volumes, dose rate, etc.), the radiation-induced immune response may vary.<\/p><p>In our team, we are studying the impact of these RT parameters on the anti-tumor immunoactivating and pro-tumor immunosuppressive response in order to optimize combinations of RT with appropriate immunotherapies.<\/p><p><img decoding=\"async\" src=\"http:\/\/inserm-u1231.u-bourgogne.fr\/img\/Mirjolet.jpg\" alt=\"\" \/><\/p><p>Figure 1 : Radiotherapy in dependence of the fractionation schedule recruits different type of immune cells and can modulate the immunotherapy target expression (Boustani et al., 2019, Cancers)<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Therapies and Immune REsponse in CancerS : TIRECS Tumors are frequently characterized by the presence of an inflammatory environment and the presence of an immune cell infiltrate. Our research team focuses on the relationships between cancer cells, inflammation and intratumoral immune response. We develop biomarker &#8230; <a title=\"01-Theme &#8211; Anglais\" class=\"read-more\" href=\"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/\" aria-label=\"En savoir plus sur 01-Theme &#8211; Anglais\">Lire la suite<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-2659","page","type-page","status-publish"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.5 - aioseo.com -->\n\t<meta name=\"description\" content=\"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.5\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_FR\" \/>\n\t\t<meta property=\"og:site_name\" content=\"CTM -\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"01-Theme \u2013 Anglais - CTM\" \/>\n\t\t<meta property=\"og:description\" content=\"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2023-09-08T08:50:28+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2023-09-08T11:57:38+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"01-Theme \u2013 Anglais - CTM\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ctm.ube.fr\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#listItem\",\"name\":\"01-Theme &#8211; Anglais\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#listItem\",\"position\":2,\"name\":\"01-Theme &#8211; Anglais\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#listItem\",\"name\":\"Home\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#organization\",\"name\":\"CTM\",\"url\":\"https:\\\/\\\/ctm.ube.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/ctm.ube.fr\\\/wp-content\\\/uploads\\\/2024\\\/02\\\/CTM-LOGO-350_70.jpg\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#organizationLogo\",\"width\":350,\"height\":70},\"image\":{\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#organizationLogo\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#webpage\",\"url\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/\",\"name\":\"01-Theme \\u2013 Anglais - CTM\",\"description\":\"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are\",\"inLanguage\":\"fr-FR\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/index.php\\\/01-theme-anglais\\\/#breadcrumblist\"},\"datePublished\":\"2023-09-08T08:50:28+00:00\",\"dateModified\":\"2023-09-08T11:57:38+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#website\",\"url\":\"https:\\\/\\\/ctm.ube.fr\\\/\",\"name\":\"CTM\",\"inLanguage\":\"fr-FR\",\"publisher\":{\"@id\":\"https:\\\/\\\/ctm.ube.fr\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"01-Theme \u2013 Anglais - CTM","description":"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are","canonical_url":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/ctm.ube.fr\/#listItem","position":1,"name":"Home","item":"https:\/\/ctm.ube.fr\/","nextItem":{"@type":"ListItem","@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#listItem","name":"01-Theme &#8211; Anglais"}},{"@type":"ListItem","@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#listItem","position":2,"name":"01-Theme &#8211; Anglais","previousItem":{"@type":"ListItem","@id":"https:\/\/ctm.ube.fr\/#listItem","name":"Home"}}]},{"@type":"Organization","@id":"https:\/\/ctm.ube.fr\/#organization","name":"CTM","url":"https:\/\/ctm.ube.fr\/","logo":{"@type":"ImageObject","url":"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg","@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#organizationLogo","width":350,"height":70},"image":{"@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#organizationLogo"}},{"@type":"WebPage","@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#webpage","url":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/","name":"01-Theme \u2013 Anglais - CTM","description":"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are","inLanguage":"fr-FR","isPartOf":{"@id":"https:\/\/ctm.ube.fr\/#website"},"breadcrumb":{"@id":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/#breadcrumblist"},"datePublished":"2023-09-08T08:50:28+00:00","dateModified":"2023-09-08T11:57:38+00:00"},{"@type":"WebSite","@id":"https:\/\/ctm.ube.fr\/#website","url":"https:\/\/ctm.ube.fr\/","name":"CTM","inLanguage":"fr-FR","publisher":{"@id":"https:\/\/ctm.ube.fr\/#organization"}}]},"og:locale":"fr_FR","og:site_name":"CTM -","og:type":"article","og:title":"01-Theme \u2013 Anglais - CTM","og:description":"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are","og:url":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/","og:image":"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg","og:image:secure_url":"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg","article:published_time":"2023-09-08T08:50:28+00:00","article:modified_time":"2023-09-08T11:57:38+00:00","twitter:card":"summary_large_image","twitter:title":"01-Theme \u2013 Anglais - CTM","twitter:description":"Back Back CADIR : F. GHIRINGHELLI Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. Yalcin Therapies and Immune REsponse in CancerS : TIRECS Tumors are","twitter:image":"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/02\/CTM-LOGO-350_70.jpg"},"aioseo_meta_data":{"post_id":"2659","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2023-09-29 14:43:06","updated":"2025-08-13 18:24:49","seo_analyzer_scan_date":null,"focus_keyword":null,"additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/ctm.ube.fr\/\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t01-Theme \u2013 Anglais\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/ctm.ube.fr\/"},{"label":"01-Theme &#8211; Anglais","link":"https:\/\/ctm.ube.fr\/index.php\/01-theme-anglais\/"}],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/pages\/2659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/comments?post=2659"}],"version-history":[{"count":8,"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/pages\/2659\/revisions"}],"predecessor-version":[{"id":2739,"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/pages\/2659\/revisions\/2739"}],"wp:attachment":[{"href":"https:\/\/ctm.ube.fr\/index.php\/wp-json\/wp\/v2\/media?parent=2659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}