{"id":2712,"date":"2023-09-08T11:48:37","date_gmt":"2023-09-08T11:48:37","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=2712"},"modified":"2023-10-02T08:56:44","modified_gmt":"2023-10-02T08:56:44","slug":"02-theme-anglais","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/02-theme-anglais\/","title":{"rendered":"02-Theme &#8211; Anglais"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2712\" class=\"elementor elementor-2712\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d7b4094 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d7b4094\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"make-column-clickable-elementor elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a65d8c2\" data-column-clickable=\"https:\/\/ctmtest2.fr\/02-menu\/\" data-column-clickable-blank=\"_self\" data-id=\"a65d8c2\" data-element_type=\"column\" data-e-type=\"column\"><a href=\"https:\/\/ctmtest2.fr\/02-menu\/\" class=\"make-column-clickable-link\"><span class=\"make-column-clickable-text\">Back<\/span><\/a>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0997d0f elementor-widget elementor-widget-button\" data-id=\"0997d0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/02-menu-anglais\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Back<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b263003\" data-id=\"b263003\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd6ecc0 elementor-widget elementor-widget-heading\" data-id=\"bd6ecc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Epi2THM : M.CALLANAN<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f23e3ff elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f23e3ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-4d0afe0\" data-id=\"4d0afe0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9e09024 hfe-menu-item-flex-end hfe-submenu-icon-arrow hfe-link-redirect-child elementor-widget 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data-widget_type=\"navigation-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"hfe-nav-menu hfe-layout-expandible hfe-nav-menu-layout expandible\" data-layout=\"expandible\">\n\t\t\t\t<div role=\"button\" class=\"hfe-nav-menu__toggle elementor-clickable\" tabindex=\"0\" aria-label=\"Basculer le menu\">\n\t\t\t\t\t<span class=\"screen-reader-text\">Menu<\/span>\n\t\t\t\t\t<div class=\"hfe-nav-menu-icon\">\n\t\t\t\t\t\t<i aria-hidden=\"true\"  class=\"fas fa-align-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<nav class=\"hfe-dropdown-expandible hfe-nav-menu__layout-expandible hfe-nav-menu__submenu-arrow\" data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-right&quot;&gt;&lt;\/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;\/i&gt;\" data-full-width=\"yes\">\n\t\t\t\t\t<ul id=\"menu-1-9e09024\" class=\"hfe-nav-menu\"><li id=\"menu-item-2693\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/01-menu-anglais\/\" class = \"hfe-menu-item\">CADIR : F. Ghiringhelli<\/a><\/li>\n<li id=\"menu-item-2962\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/02-menu-anglais\/\" class = \"hfe-menu-item\">Epi2THM : M. Callanan<\/a><\/li>\n<li id=\"menu-item-2963\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/03-menu-anglais\/\" class = \"hfe-menu-item\">HSP-PATHIES : C. Garrido<\/a><\/li>\n<li id=\"menu-item-2961\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/descartes_team\/\" class = \"hfe-menu-item\">DESCARTES : O. Micheau<\/a><\/li>\n<li id=\"menu-item-2964\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/04-menu-anglais\/\" class = \"hfe-menu-item\">EPICAD : C. Lepage<\/a><\/li>\n<li id=\"menu-item-2967\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/www.gad-bfc.org\/\" class = \"hfe-menu-item\">GAD : C. Thauvin<\/a><\/li>\n<li id=\"menu-item-2965\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/06-menu-anglais\/\" class = \"hfe-menu-item\">PADYS : B. Verg\u00e8s<\/a><\/li>\n<li id=\"menu-item-2966\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/07-menu-anglais\/\" class = \"hfe-menu-item\">NUTOX : N. Kahn<\/a><\/li>\n<li id=\"menu-item-2960\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/08-menu-anglais\/\" class = \"hfe-menu-item\">LIPNESS : D. Masson<\/a><\/li>\n<li id=\"menu-item-2968\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/blog.u-bourgogne.fr\/yalcingroup\/\" class = \"hfe-menu-item\">B. Yalcin<\/a><\/li>\n<\/ul> \n\t\t\t\t<\/nav>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-93a2fa7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"93a2fa7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5d85e39\" data-id=\"5d85e39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f8349d elementor-widget elementor-widget-heading\" data-id=\"5f8349d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Epigenetics, epidemiology and personalized treatment of hematological malignancies: Epi2THM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-897c5d8 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"897c5d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"521\" src=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2023\/08\/eq2-1-1-768x521.jpg\" class=\"attachment-medium_large size-medium_large wp-image-2188\" alt=\"\" srcset=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2023\/08\/eq2-1-1-768x521.jpg 768w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2023\/08\/eq2-1-1-300x203.jpg 300w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2023\/08\/eq2-1-1-1024x694.jpg 1024w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2023\/08\/eq2-1-1.jpg 1425w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0fa2856 elementor-widget elementor-widget-text-editor\" data-id=\"0fa2856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The team has 3 interconnecting research themes that are globally aimed at innovation in the personalised prevention, diagnosis\/prognosis and treatment of blood cancers with focus on leukemia and B cell lymphoma.<\/p><ul><li>1- elucidate new (epi)genetic disease mechanisms of interest as predictive risk factors or for therapeutic targeting in leukemia and lymphoma, through high throughput (epi)genomic screens in model cellular systems and functional analyses (CRISPR-Cas9) in mouse and human systems, together with clinical validation by analyses in patient samples (curated by the team or in the setting of multicentre clinical trials)<\/li><li>2- identify, by epidemiology approaches in population-based data, factors that influence survival, access to and impact of treatment innovation and quality of life in blood cancer patients<\/li><li>3- to leverage our findings concerning patient (epidemiology and clinical) and disease characteristics [(epi)genetic], together with new residual disease diagnostic approaches (Cf DNA and imaging), for dynamic prediction of patient outcomes by precision medicine approaches.<\/li><\/ul><h4>Selected publications<\/h4><ul><li>Repeat element activation-driven inflammation; role of NFKB and implications in normal development and cancer? Dum\u00e9tier B, Sauter C, Hajmirza A, Pernon B, Aucagne R, Fournier C, Row C, Guidez F, Rossi C, Lepage C, Delva L, Callanan MB. <b>Biomedicines<\/b>, Review 2022, in press<\/li><li>Protein Arginine Methyltransferases as Therapeutic Targets in Hematological Malignancies. Sauter C, Simonet J, Guidez F, Dum\u00e9tier B, Pernon B, Callanan M, Bastie JN, Aucagne R, Delva L. <b>Cancers <\/b> (Basel), Review 2022, PMID: 36358861<\/li><li>Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase 1\/2 trial. Le Gouill S, Morschhauser F, Chiron D, Bouabdallah K, Cartron G, Casasnovas O, Bodet-Milin C, Ragot S, Bossard C, Nadal N, Herbaux C, Tessoulin B, Tchernonog E, Rossi C, McCulloch R, Gastinne T, Callanan MB*, Rule S*. <b>Blood<\/b>, 2021, PMID: 33181832 *equal contribution<\/li><li>Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21). Burlet B, Ramla S, Fournier C, Abrey-Recalde MJ, Sauter C, Chr\u00e9tien ML, Rossi C, Duffourd Y, Ragot S, Buriller C, Tournier B, Chapusot C, Nadal N, Racine J, Guy J, Bailly F, Martin L, Casasnovas O, Bastie JN, Caillot D, Albuisson J, Broccardo C, Thieblemont C, Delva L, Maynadi\u00e9 M, Aucagne R*, Callanan MB*. <b>Cold Spring Harb Mol Case Stud<\/b>, 2021, PMID: 33608382 *co-corresponding authors<\/li><li>PLZF Acetylation Levels Regulate NKT Cell Differentiation. Klibi J, Joseph C, Delord M, Teissandier A, Lucas B, Chomienne C, Toubert A, Bourc&rsquo;his D, Guidez F*, Benlagha K*. <b>J Immunol<\/b>, 2021, PMID: 34282003 *co-last, co-corresponding authors<\/li><li>Flexible Modeling of Net Survival and Cure by AML Subtype and Age: A French Population-Based Study from FRANCIM. Mounier M*, Romain G, Callanan M, Alla AD, Boussari O, Maynadi\u00e9 M, Colonna M, Jooste V. <b>J Clin Med<\/b>, 2021, PMID: 33924506 *Corresponding author.<\/li><li>High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells. Hermetet F, Mshaik R, Simonet J, Callier P, Delva L, Qu\u00e9r\u00e9 R. <b>Sci Rep<\/b>, 2020, PMID: 32999332.<\/li><li>High-fat diet disturbs lipid raft\/TGF-\u03b2 signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow. Hermetet F, Buffi\u00e8re A, Aznague A, Pais de Barros JP, Bastie JN, Delva L, Qu\u00e9r\u00e9 R. <b>Nat Commun<\/b>, 2019, PMID: 30705272<\/li><li>A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma. Gressin R, Daguindau N, Tempescul A, Moreau A, Carras S, Tchernonog E, Schmitt A, Houot R, Dartigeas C, Pignon JM, Corm S, Banos A, Mounier C, Dupuis J, Macro M, Fleury J, Jardin F, Sarkozy C, Damaj G, Feugier P, Fornecker LM, Chabrot C, Dorvaux V, Bouadallah K, Amorin S, Garidi R, Voillat L, Joly B, Celigny PS, Morineau N, Moles MP, Zerazhi H, Fontan J, Arkam Y, Alexis M, Delwail V, Vilque JP, Ysebaert L, Le Gouill S, Callanan MB; Lymphoma Study Association. <b>Haematologica<\/b>, 2019, PMID: 30171024<\/li><li>PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study. Casasnovas RO, Bouabdallah R, Brice P, Lazarovici J, Ghesquieres H, Stamatoullas A, Dupuis J, Gac AC, Gastinne T, Joly B, Bouabdallah K, Nicolas-Virelizier E, Feugier P, Morschhauser F, Delarue R, Farhat H, Quittet P, Berriolo-Riedinger A, Tempescul A, Edeline V, Maisonneuve H, Fornecker LM, Lamy T, Delmer A, Dartigues P, Martin L, Andr\u00e9 M, Mounier N, Traverse-Glehen A, Meignan M. <b>Lancet Oncol<\/b>, 2019, PMID: 30658935<\/li><li>The Need for a Consensus Next-generation Sequencing Panel for Mature Lymphoid Malignancies. Sujobert P, Le Bris Y, de Leval L, Gros A, Merlio JP, Pastoret C, Huet S, Sarkozy C, Davi F, Callanan M, Thieblemont C, Sibon D, Asnafi V, Preudhomme C, Gaulard P, Jardin F, Salles G, Macintyre E. <b>Hemasphere<\/b>, 2018, PMID: 31723808<\/li><li>Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms. Emadali A, Hoghoughi N, Duley S, Hajmirza A, Verhoeyen E, Cosset FL, Bertrand P, Roumier C, Roggy A, Suchaud-Martin C, Chauvet M, Bertrand S, Hamaidia S, Rousseaux S, Josserand V, Charles J, Templier I, Maeda T, Bruder-Costa J, Chaperot L, Plumas J, Jacob MC, Bonnefoix T, Park S, Gressin R, Tensen CP, Mecucci C, Macintyre E, Leroux D, Brambilla E, Nguyen-Khac F, Luquet I, Penther D, Bastard C, Jardin F, Lefebvre C, Garnache F, Callanan MB. <b>Blood<\/b>, 2016, PMID: 27060168<\/li><\/ul><p>1- d\u2019\u00e9lucider de nouveaux m\u00e9canismes (\u00e9pi)g\u00e9n\u00e9tiques dans les h\u00e9mopathies, mettant au jour des facteurs de risque pr\u00e9dictifs ou de nouvelles cibles th\u00e9rapeutiques, par des cribles (\u00e9pi)g\u00e9nomiques \u00e0 haut d\u00e9bit dans des syst\u00e8mes cellulaires mod\u00e8les et des analyses fonctionnelles (CRISPR-Cas9) dans des syst\u00e8mes murins et humains et de permettre une validation clinique par des analyses d&rsquo;\u00e9chantillons de patients (conserv\u00e9s par l&rsquo;\u00e9quipe ou dans le cadre d&rsquo;essais cliniques multicentriques),<br \/>2- d\u2019identifier par des approches \u00e9pid\u00e9miologiques dans des donn\u00e9es de population, les facteurs qui influencent la survie, l&rsquo;acc\u00e8s et l&rsquo;impact de l&rsquo;innovation th\u00e9rapeutique et la qualit\u00e9 de vie des patients atteints d\u2019h\u00e9mopathies malignes,<br \/>3- d\u2019exploiter nos r\u00e9sultats concernant les caract\u00e9ristiques des patients (\u00e9pid\u00e9miologiques et cliniques) et de la maladie [(\u00e9pi)g\u00e9n\u00e9tique], ainsi que les nouvelles approches de diagnostic des maladies r\u00e9siduelles (Cf. ADN et imagerie), afin d\u2019avoir une pr\u00e9diction dynamique et une approche de m\u00e9decine de pr\u00e9cision.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Back Epi2THM : M.CALLANAN Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson DESCARTES : O. Micheau B. Yalcin LIIC A. Bettaieb Epigenetics, epidemiology and personalized treatment of hematological malignancies: Epi2THM &#8230; <a title=\"02-Theme &#8211; Anglais\" class=\"read-more\" href=\"https:\/\/ctm.ube.fr\/index.php\/02-theme-anglais\/\" aria-label=\"En savoir plus sur 02-Theme &#8211; Anglais\">Lire la suite<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2712","page","type-page","status-publish"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.5 - aioseo.com -->\n\t<meta name=\"description\" content=\"Back Back Epi2THM : M.CALLANAN Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. 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