{"id":4176,"date":"2024-01-02T14:05:04","date_gmt":"2024-01-02T14:05:04","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=4176"},"modified":"2026-01-07T07:44:16","modified_gmt":"2026-01-07T07:44:16","slug":"09-theme-fr","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/09-theme-fr\/","title":{"rendered":"09-Theme &#8211; fr"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4176\" class=\"elementor elementor-4176\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca9e50e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca9e50e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"make-column-clickable-elementor elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-fc34845\" data-column-clickable=\"https:\/\/ctmtest2.fr\/01-menu\/\" data-column-clickable-blank=\"_self\" data-id=\"fc34845\" data-element_type=\"column\" data-e-type=\"column\"><a href=\"https:\/\/ctmtest2.fr\/01-menu\/\" class=\"make-column-clickable-link\"><span class=\"make-column-clickable-text\">Back<\/span><\/a>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-634f7aa elementor-widget elementor-widget-button\" data-id=\"634f7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/equipe-descartes\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-left\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Back<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-253fdf7\" data-id=\"253fdf7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6e39dc elementor-widget elementor-widget-heading\" data-id=\"a6e39dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-xl\">DESCARTES: O. Micheau <\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20e3194 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"20e3194\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b806867\" data-id=\"b806867\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-714b078 hfe-menu-item-flex-end hfe-submenu-icon-arrow hfe-link-redirect-child elementor-widget elementor-widget-navigation-menu\" data-id=\"714b078\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;hamburger_menu_align&quot;:&quot;flex-end&quot;,&quot;padding_horizontal_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;hamburger_align&quot;:&quot;center&quot;,&quot;dropdown_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;dropdown_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;padding_horizontal_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_horizontal_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;padding_vertical_dropdown_item_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;distance_from_menu_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_size_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;toggle_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"navigation-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"hfe-nav-menu hfe-layout-expandible hfe-nav-menu-layout expandible\" data-layout=\"expandible\">\n\t\t\t\t<div role=\"button\" class=\"hfe-nav-menu__toggle elementor-clickable\" tabindex=\"0\" aria-label=\"Basculer le menu\">\n\t\t\t\t\t<span class=\"screen-reader-text\">Menu<\/span>\n\t\t\t\t\t<div class=\"hfe-nav-menu-icon\">\n\t\t\t\t\t\t<i aria-hidden=\"true\"  class=\"fas fa-align-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<nav class=\"hfe-dropdown-expandible hfe-nav-menu__layout-expandible hfe-nav-menu__submenu-arrow\" data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-right&quot;&gt;&lt;\/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;\/i&gt;\" data-full-width=\"yes\">\n\t\t\t\t\t<ul id=\"menu-1-714b078\" class=\"hfe-nav-menu\"><li id=\"menu-item-2693\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/01-menu-anglais\/\" class = \"hfe-menu-item\">CADIR : F. Ghiringhelli<\/a><\/li>\n<li id=\"menu-item-2962\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/02-menu-anglais\/\" class = \"hfe-menu-item\">Epi2THM : M. Callanan<\/a><\/li>\n<li id=\"menu-item-2963\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/03-menu-anglais\/\" class = \"hfe-menu-item\">HSP-PATHIES : C. Garrido<\/a><\/li>\n<li id=\"menu-item-2961\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/descartes_team\/\" class = \"hfe-menu-item\">DESCARTES : O. Micheau<\/a><\/li>\n<li id=\"menu-item-2964\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/04-menu-anglais\/\" class = \"hfe-menu-item\">EPICAD : C. Lepage<\/a><\/li>\n<li id=\"menu-item-2967\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/www.gad-bfc.org\/\" class = \"hfe-menu-item\">GAD : C. Thauvin<\/a><\/li>\n<li id=\"menu-item-2965\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/06-menu-anglais\/\" class = \"hfe-menu-item\">PADYS : B. Verg\u00e8s<\/a><\/li>\n<li id=\"menu-item-2966\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/07-menu-anglais\/\" class = \"hfe-menu-item\">NUTOX : N. Kahn<\/a><\/li>\n<li id=\"menu-item-2960\" class=\"menu-item menu-item-type-post_type menu-item-object-page parent hfe-creative-menu\"><a href=\"https:\/\/ctm.ube.fr\/index.php\/08-menu-anglais\/\" class = \"hfe-menu-item\">LIPNESS : D. Masson<\/a><\/li>\n<li id=\"menu-item-2968\" class=\"menu-item menu-item-type-custom menu-item-object-custom parent hfe-creative-menu\"><a href=\"https:\/\/blog.u-bourgogne.fr\/yalcingroup\/\" class = \"hfe-menu-item\">B. Yalcin<\/a><\/li>\n<\/ul> \n\t\t\t\t<\/nav>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d5625a0 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d5625a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-410bd85\" data-id=\"410bd85\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3bac779 elementor-widget elementor-widget-heading\" data-id=\"3bac779\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Th\u00e8mes de recherche :<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672c02b elementor-widget elementor-widget-accordion\" data-id=\"672c02b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1081\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1081\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"><\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1081\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1081\"><p><em>cliquez ci-dessous pour prendre connaissance de nos axes de recherche\u00a0<\/em><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1082\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1082\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> Signalisation TRAIL et transduction du signal<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1082\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1082\"><div id=\"collapseOne\" class=\"accordion-body in collapse\"><div class=\"accordion-inner\"><ul><li><strong>Olivier Micheau<\/strong> (DR2 INSERM) &#8211; <a href=\"omicheau@u-bourgogne.fr\">mail<\/a><\/li><li>Abdelmnim Radoua (Post-Doc)<\/li><li>Jiajia Wang (Doc)<\/li><li>Thomas Brancaccio (M2R)<\/li><\/ul><p><strong>Collaborations<\/strong> : Philippe Krebs (<a href=\"https:\/\/www.igmp.unibe.ch\/research\/research_groups\/group_krebs\/index_eng.html\">Institute of Tissue Medicine and Pathology<\/a>, Univ Bern; Switzerland); Eva Szegezdi (Apoptosis research center, <a href=\"https:\/\/www.universityofgalway.ie\/our-research\/people\/evaszegezdi\/\">Univ Galway<\/a>, Ireland); \u00a0Aristotelis Chatziioannou (<a href=\"http:\/\/www.bioacademy.gr\/faculty-details\/HMiK\/aristotelis\">Biomedical Research Foundation Academy of Athens<\/a>, Greece); Gerhard Wingender (<a href=\"https:\/\/www.wingenderlab.org\">Izmir Biomedicine &amp; genome center<\/a>, IBG Turkey); <strong>Financement<\/strong>\u00a0: MSCA <a href=\"https:\/\/cordis.europa.eu\/project\/id\/777995\">DISCOVER<\/a> 2018_2022 and MSCA <a href=\"https:\/\/www.trail4life.eu\/chiron\">CHIRON<\/a> 2023-2027<\/p><p><strong>Rationnel<\/strong> :\u00a0Au cours des 5 derni\u00e8res ann\u00e9es, notre \u00e9quipe a contribu\u00e9 \u00e0 des avanc\u00e9es significatives dans la compr\u00e9hension des m\u00e9canismes mol\u00e9culaires r\u00e9gulant la transduction du signal induite par TRAIL.<\/p><p>Par exemple, nous avons d\u00e9montr\u00e9 que :<\/p><ul><li>DR4 est N-glycosyl\u00e9 et que cette modification post-traductionnelle contribue \u00e0 l&rsquo;initiation de l&rsquo;apoptose induite par TRAIL.<\/li><li>L&rsquo;apoptose induite par TRAIL implique pr\u00e9f\u00e9rentiellement DR4.<\/li><li>DR5, contrairement \u00e0 DR4, est capable de transduire la motilit\u00e9 cellulaire.<\/li><li>Comme DR5, cependant, DR4 est \u00e9galement capable d&rsquo;induire l&rsquo;apoptose de mani\u00e8re ind\u00e9pendante des ligands en r\u00e9ponse au stress du r\u00e9ticulum endoplasmique.<\/li><\/ul><p>Si les acteurs et les modalit\u00e9s de la r\u00e9gulation de l&rsquo;apoptose induite par DR4 ou DR5 sont connus, ceux qui gouvernent la motilit\u00e9 cellulaire induite par DR5 ne le sont pas. <strong>Des travaux sont en cours dans notre \u00e9quipe pour identifier les partenaires prot\u00e9iques de DR5 responsables de la signalisation non-canonique de TRAIL.\u00a0<\/strong><\/p><p><span style=\"text-decoration: underline;\">Publications de l&rsquo;\u00e9quipe sur le sujet <span style=\"font-size: inherit;\">:<\/span><\/span><\/p><ul><li>Airiau K, Vacher P, Micheau O, Prouzet-Mauleon V, Kroemer G, Moosavi MA, Djavaheri-Mergny M. TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex. <a href=\"https:\/\/www.mdpi.com\/2073-4409\/11\/1\/57\" target=\"_blank\" rel=\"noopener\">Cells<\/a> 2021;11(1):57.<\/li><li>Micheau O, Rizzi M, Smulski CR. Editorial: TNFR Superfamily Oligomerization and Signaling. <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.682472\/full\" target=\"_blank\" rel=\"noopener\">Front Cell Dev Biol<\/a> 2021;9:682472.<\/li><li>Cardoso Alves L, Corazza N, Micheau O, Krebs P. The multifaceted role of TRAIL signaling in cancer and immunity. <a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15637\" target=\"_blank\" rel=\"noopener\">FEBS J<\/a> 2021;288(19):5530-5554.<\/li><li>Micheau O. Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation. <a href=\"https:\/\/www.mdpi.com\/1422-0067\/19\/3\/715\" target=\"_blank\" rel=\"noopener\">Int J Mol Sci<\/a> 2018;19(3):715.<\/li><li>Dufour F, Rattier T, Constantinescu AA, Zischler L, Morl\u00e9 A, Ben Mabrouk H, Humblin E, Jacquemin G, Szegezdi E, Delacote F, Marrakchi N, Guichard G, Pellat-Deceunynck C, Vacher P, Legembre P, Garrido C, Micheau O. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. <a href=\"https:\/\/www.oncotarget.com\/article\/14285\/text\/\" target=\"_blank\" rel=\"noopener\">Oncotarget<\/a> 2017;8(6):9974-9985.<\/li><li>Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morl\u00e9 A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O. N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. <a href=\"https:\/\/www.nature.com\/articles\/cdd2016150\" target=\"_blank\" rel=\"noopener\">Cell Death Differ<\/a> 2017;24(3):500-510.<\/li><\/ul><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1083\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1083\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">R\u00e9gulation post-traductionnelle des ligands et r\u00e9cepteurs de la super famille du TNF par le NO <\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1083\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1083\"><ul><li><strong>St\u00e9phanie Plenchette <\/strong>\u00a0(PI, MCU,\u00a0<a href=\"https:\/\/www.ephe.psl.eu\">EPHE<\/a>) &#8211; <a href=\"mailto:&quot;Stephanie.Plenchette-Colas@u-bourgogne.fr&quot;\">mail<\/a><\/li><li>Olivier Micheau (DR2 INSERM)\u00a0<\/li><li>Elayne Neirynck (Doc)<\/li><li>Flavie Gaucher (AI EPHE)<\/li><li>Manon Lescutier (Tec INSERM)<\/li><\/ul><p><strong>Collaborations<\/strong> :<span lang=\"FR\">Fabrice Neiers (INRAE) <\/span> ; <strong>Financement<\/strong> : INCa <a href=\"https:\/\/www.e-cancer.fr\/Institut-national-du-cancer\/Appels-a-projets\/Appels-a-projets-resultats\/PLBIO2022\">PLBIO22<\/a> 2022_2026; MSCA <a href=\"https:\/\/www.universityofgalway.ie\/cancercentre\/research\/no-cancer-net\/\">NO-CANCER-NET<\/a> 2023_2027\u00a0<\/p><div>\u00a0<\/div><p><strong>Rationnel :<\/strong><\/p><div><span lang=\"FR\">Les membres de la famille TNF, y compris les r\u00e9cepteurs contenant un domaine de mort ou leurs ligands respectifs, peuvent subir des modifications post-traductionnelles (MPT). Une meilleure compr\u00e9hension de l\u2019importance de ces MPTs au sein du microenvironnement tumoral est susceptible de fournir des opportunit\u00e9s th\u00e9rapeutiques inattendues. Nous nous int\u00e9ressons tout particuli\u00e8rement \u00e0 la S-nitrosylation, une MPT induite par le monoxyde d\u2019azote (NO) sur les cyst\u00e9ines. <b>Nous \u00e9tudions comment des m\u00e9dicaments donneurs de NO r\u00e9gulent la signalisation des membres de la famille TNF ainsi que d\u2019autres cytokines pro-inflammatoires dans le but de d\u00e9finir de nouvelles strat\u00e9gies th\u00e9rapeutiques anticanc\u00e9reuses. <\/b><\/span><\/div><div>\u00a0<\/div><p><span style=\"text-decoration: underline;\">Publications de l&rsquo;\u00e9quipe sur le sujet<\/span> :<\/p><ul><li>Meunier M, Yammine A, Bettaieb A, Plenchette S. Nitroglycerin : a comprehensive review in cancer therapy. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37173331\/\">Cell Death and Disease<\/a> 2023; May 12;14(5):323.<\/li><li>Bouaouiche S, Ghione S, Sgahier S, Burgy O, Racoeur C, Derang\u00e8re V, Bettaieb A, Plenchette S. Nitric oxide-releasing drug Glyceryl trinitrate targets JAK2\/STAT3 signaling migration and invasion of triple-negative breast cancer cells. <a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8449\">International Journal of Molecular Science<\/a> 2021; 22(16):8449.<\/li><li>Gu\u00e9rin E, Meunier M, Plenchette S. IAPs and cancer: the NO strikes back. <a href=\"https:\/\/www.medecinesciences.org\/en\/articles\/medsci\/full_html\/2021\/06\/msc200560\/msc200560.html\">M\u00e9decine Sciences<\/a> 2021; 37(6-7):681-683. <br \/>Micheau O, Rizzi M, Smulski CR. Editorial: TNFR Superfamily Oligomerization and Signaling. <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.682472\/full\" target=\"_blank\" rel=\"noopener\">Front Cell Dev Biol<\/a> 2021;9:682472.<\/li><li><span style=\"font-size: inherit;\">Romagny S, Bouaouiche S, Lucchi G, Ducoroy P, Bertoldo JB, Terenzi H, Bettaieb A, Plenchette S (2018) S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFalpha\/TNFR1-Mediated Cell Survival to Cell Death. <\/span><a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8449\"><i style=\"font-size: inherit;\">Cancer Research<\/i><\/a><span style=\"font-size: inherit;\"> 78: 1948-1957.<\/span><\/li><li><div><span lang=\"EN-US\">Bettaieb A, Paul C, Plenchette S. Exploration of Fas S-nitrosylation b the Biotin Switch Assay. <a href=\"https:\/\/link.springer.com\/protocol\/10.1007\/978-1-4939-6780-3_18\"><i>Methods in Molecular Biology<\/i><\/a> 2017; 1557:199-206.\u00a0<\/span><\/div><\/li><li>\u00a0<span style=\"font-size: inherit;\">Plenchette S, Romagny S, Laurens V, Bettaieb A (2016) [NO and cancer: itinerary of a double agent]. <\/span><i style=\"font-size: inherit;\"><a href=\"https:\/\/www.medecinesciences.org\/en\/articles\/medsci\/full_html\/2016\/07\/medsci20163206p625\/medsci20163206p625.html\">Med Sci<\/a> (Paris)<\/i><span style=\"font-size: inherit;\"> 32: 625-633.<\/span><\/li><li><span lang=\"EN-US\"><span lang=\"EN-US\">Plenchette S (2015) Role Of S-Nitrosylation In The Extrinsic Apoptotic Signalling Pathway In Cancer. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213231715001287?via%3Dihub\"><i>Redox Biol<\/i><\/a> 5: 415.<\/span><\/span><\/li><li><span lang=\"EN-US\"><span lang=\"EN-US\">Bettaieb A, Plenchette S, Paul C, Laurens V, Romagny S and Jeannin JF. S-nitrosylation in cancer cell: to prevent or to cause? <i>Nitric oxide and Cancer: Pathogenesis and Therapy<\/i> 2015; p97-109.<\/span><\/span><\/li><li><div>\u00a0<span style=\"font-size: inherit;\">Leon-Bollotte L, Subramaniam S, Cauvard O, Plenchette-Colas S, Paul C, Godard C, Martinez-Ruiz A, Legembre P, Jeannin JF, Bettaieb A (2011) S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells. <\/span><a href=\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(11)00264-2\/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F\"><i style=\"font-size: inherit;\">Gastroenterology<\/i><\/a><span style=\"font-size: inherit;\"> 140: 2009-2018.<\/span><\/div><\/li><\/ul><div>\u00a0<\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1084\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1084\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Conception th\u00e9rapeutique de nouvelles formulations de d\u00e9riv\u00e9s de TRAIL<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1084\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1084\"><p><strong>Equipe :<\/strong><\/p><ul><li><strong>Olivier Micheau<\/strong> (DR2 INSERM) &#8211; <a href=\"mailto:&quot;omicheau@u-bourgogne.fr&quot;\">mail<\/a><\/li><li>Johanna Chluba (PR, <a href=\"https:\/\/www.u-bourgogne.fr\">UB<\/a>)<\/li><li>Abdelmnim Radoua (Post-Doc)<\/li><li>Bachar Alrustom (AI INSERM)<\/li><li>Alanis Linares (M2R)<\/li><\/ul><p><strong>Collaborations<\/strong> : Said El Alaoui (<a href=\"https:\/\/www.covalab.com\">Covalab<\/a>, Lyon); Nadine Millot (<a href=\"https:\/\/icb.u-bourgogne.fr\/en\/home-page\/homepage\/\">ICB<\/a>, Univ Bourgogne); Guillaume Herlem et Fabien Picaud (<a href=\"https:\/\/www.lnit.fr\">NIT &#8211; Nanom\u00e9decine, Imagerie, Th\u00e9rapeutique<\/a>, Besan\u00e7on); \u00a0<strong>Financement<\/strong> : <a href=\"https:\/\/anr.fr\">ANR<\/a> Labcom <a href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/labcom_iam-it\/\">IAM-IT<\/a> 2023-2028\u00a0<\/p><p><strong>Rationnel<\/strong> :\u00a0<span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">Le manque d&rsquo;efficacit\u00e9 de la premi\u00e8re g\u00e9n\u00e9ration de m\u00e9dicaments bas\u00e9s sur TRAIL ou ses d\u00e9riv\u00e9s a jet\u00e9 le doute sur son utilit\u00e9 en oncologie<\/span><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">.\u00a0<\/span><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">Cependant, de nouvelles formulations sont envisageables pour augmenter le potentiel th\u00e9rapeutique de TRAIL.\u00a0<\/span><\/p><p><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">Par exemple, nous avons d\u00e9montr\u00e9 qu&rsquo;il est possible d&rsquo;augmenter significativement la sensibilit\u00e9 des cellules tumorales r\u00e9sistantes \u00e0 TRAIL en :<\/span><\/p><ul><li>le fonctionnalisant sur des nanoparticules<\/li><li>le combinant avec une hyperthermie mod\u00e9r\u00e9e<\/li><li>ou en le fonctionnalisant sur des nanoparticules d&rsquo;oxyde de fer pour induire \u00e0 distance une hyperthermie mod\u00e9r\u00e9e \u00e0 l&rsquo;aide d&rsquo;un champ magn\u00e9tique ou d&rsquo;un laser.<\/li><\/ul><p>Nous avons \u00e9galement entam\u00e9 une collaboration fructueuse avec <a style=\"font-size: inherit;\" href=\"https:\/\/www.covalab.com\/eu\/\" target=\"_blank\" rel=\"noopener\">Covalab <\/a><span style=\"font-size: inherit;\">pour g\u00e9n\u00e9rer de nouveaux anticorps th\u00e9rapeutiques ciblant DR4 et DR5. <strong>Nous poursuivons nos travaux en vue d&rsquo;une application clinique.<\/strong><\/span><\/p><p><span style=\"text-decoration: underline;\">Publications de l&rsquo;\u00e9quipe sur le sujet :<\/span><\/p><ul><li>Belkahla H, Constantinescu AA, Gharbi T, Barbault F, Chevillot-Biraud A, Decorse P, Micheau O, H\u00e9madi M, Ammar S. Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency <a href=\"https:\/\/www.mdpi.com\/2079-4991\/11\/2\/502\" target=\"_blank\" rel=\"noopener\">Nanomaterials<\/a> 2021;11(2):507.<\/li><li>Belkahla H, Mazar\u00edo E, Sangnier AP, Lomas JS, Gharbi T, Ammar S, Micheau O, Wilhelm C, H\u00e9madi M. TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia. <a href=\"https:\/\/www.thno.org\/v09p5924.htm\" target=\"_blank\" rel=\"noopener\">Theranostics<\/a> 2019;9(20):5924-5936.<\/li><li>Dubuisson A, Favreau C, Fourmaux E, Lareure S, Rodrigues-Saraiva R, Pellat-Deceunynck C, El Alaoui S, Micheau O. Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy. <a href=\"https:\/\/www.nature.com\/articles\/s41419-019-1343-5\" target=\"_blank\" rel=\"noopener\">Cell Death Dis<\/a> 2019;10(2):101.<\/li><li>Dubuisson A, Micheau O. Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy. <a href=\"https:\/\/www.mdpi.com\/2073-4468\/6\/4\/16\" target=\"_blank\" rel=\"noopener\">Antibodies<\/a> 2017;6(4):16.<\/li><li>Morl\u00e9 A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. <a href=\"https:\/\/www.nature.com\/articles\/cddis201512\" target=\"_blank\" rel=\"noopener\">Cell Death Dis<\/a> 2015;6(2):e1633.<\/li><li>Zakaria AB, Picaud F, Rattier T, Pudlo M, Dufour F, Saviot L, Chassagnon R, Lherminier J, Gharbi T, Micheau O, Herlem G. Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/nl503565t\" target=\"_blank\" rel=\"noopener\">Nano Lett<\/a> 2015;15(2):891-895.<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Back DESCARTES: O. Micheau Menu CADIR : F. Ghiringhelli Epi2THM : M. Callanan HSP-PATHIES : C. Garrido DESCARTES : O. Micheau EPICAD : C. Lepage GAD : C. Thauvin PADYS : B. Verg\u00e8s NUTOX : N. Kahn LIPNESS : D. Masson B. 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