{"id":5446,"date":"2024-04-08T15:14:24","date_gmt":"2024-04-08T15:14:24","guid":{"rendered":"https:\/\/ctm.u-bourgogne.fr\/?page_id=5446"},"modified":"2024-04-08T20:02:39","modified_gmt":"2024-04-08T20:02:39","slug":"phd-in-the-descartes-team-2","status":"publish","type":"page","link":"https:\/\/ctm.ube.fr\/index.php\/phd-in-the-descartes-team-2\/","title":{"rendered":"PhD in the DesCarTes Team  ICE"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"5446\" class=\"elementor elementor-5446\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3a68c42 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a68c42\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-309dab7\" data-id=\"309dab7\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c355c4c elementor-widget elementor-widget-text-editor\" data-id=\"c355c4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"margin: 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000;\" align=\"center\"><b><span lang=\"FR\" style=\"font-family: Arial, sans-serif;\">DISPOSITIF \u00ab\u00a0<a href=\"https:\/\/www.bourgognefranchecomte.fr\/node\/1698\">ITINERAIRE CHERCHEURS ENTREPRENEURS<\/a> &#8211; ICE\u00a0\u00bb<\/span><\/b><\/p><p style=\"margin: 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000;\" align=\"center\"><b><span lang=\"FR\" style=\"font-family: Arial, sans-serif;\">Dossier de PROJET DE THESE<\/span><\/b><\/p><p><b style=\"caret-color: #000000; color: #000000; text-align: start;\"><span lang=\"EN-US\" style=\"font-size: 12pt; font-family: Arial, sans-serif; border: medium;\">Ann\u00e9e 2024<\/span><\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ab76d1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ab76d1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-80d8246\" data-id=\"80d8246\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2fc291d elementor-widget elementor-widget-heading\" data-id=\"2fc291d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Humanisation de cibles th\u00e9rapeutiques chez le rongeur pour valider les nouvelles bioth\u00e9rapies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aeb801b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aeb801b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dcaf999\" data-id=\"dcaf999\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b91a2cf elementor-widget elementor-widget-text-editor\" data-id=\"b91a2cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\"><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">PhD Supervisor\u00a0\u00a0 : Joanna Chluba \u00a0<\/span><a style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\" href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/descartes_team\/\">CTM TEAM DesCarTes<\/a><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif;\"> (Death-Domain containing TNF-receptor Signal transduction and cancer therapies)<\/span><\/p><ul><li>Research center :\u00a0 <strong>Center for Translational Molecular Medicine (INSERM) U1231 <\/strong><\/li><li>localisation : 7 Bd Jeanne d\u2019Arc, <strong>Dijon, France<\/strong><\/li><li><strong>contact: joanna.chluba\u00a0<strong>[at] u-bourgogne.fr et\u00a0<\/strong>omicheau [at] u-bourgogne.fr <\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a8a5ce8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a8a5ce8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6ab49ef\" data-id=\"6ab49ef\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ead5905 elementor-widget elementor-widget-text-editor\" data-id=\"ead5905\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Thesis project description<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a9a514b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a9a514b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-26647ad\" data-id=\"26647ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c8cee1 elementor-widget elementor-widget-text-editor\" data-id=\"6c8cee1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\"><strong><u>Positionnement du sujet\u00a0:<\/u><\/strong><\/p><p style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u00a0 L\u2019essor des me\u0301dicaments produits a\u0300 partir du vivant ou biome\u0301dicaments telles que les anticorps monoclonaux ou les th\u00e9rapies cellulaires de type CAR-T ou NK-T cells, qui en d\u00e9coulent, <strong>re\u0301volutionnent les pratiques th\u00e9rapeutiques et l\u2019industrie pharmaceutique<\/strong>.<\/p><p style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u00a0 Le domaine des biothe\u0301rapies et bioproduction de the\u0301rapies innovantes est l\u2019une des 3 priorite\u0301s du Plan Innovation Sante\u0301 de France2030, avec pr\u00e8s de 7.5 milliards d\u2019euros pr\u00e9vus pour faire de la france la premi\u00e8re nation europ\u00e9enne en sant\u00e9. Le march\u00e9 des bioth\u00e9rapie a \u00e9t\u00e9 estim\u00e9 \u00e0 pr\u00e8s de 320 milliards d\u2019euros d\u2019ici 2025 et represente 24.3% du march\u00e9 du m\u00e9dicament en 2019. \u00c0 moyen terme le march\u00e9 des bioth\u00e9rapies pourrait repr\u00e9senter plus de 32% du march\u00e9 mondial.<\/p><p style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u00a0 Parmis les th\u00e9matiques vis\u00e9es pour se d\u00e9marquer dans le plan 2030, figure \u201c<strong>Les biotechnologies en oncologie et notamment les anticorps monoclonaux ou les CAR-T cells<\/strong> ciblant par exemple les cellules malignes de certaines leuc\u00e9mies ou lymphomes\u201d . C\u2019est pr\u00e9cis\u00e9ment dans ce cadre que le sujet de th\u00e8se s\u2019inscrit, fort de l\u2019expertise de notre \u00e9quipe de recherche qui vient d\u2019obtenir un financement ANR LabCom, projet<a href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/labcom_iam-it\/\"> IAM-IT<\/a> (Laboratoire Commun d\u2019Inge\u0301nierie des Anticorps Monoclonaux Innovants a\u0300 vise\u0301e The\u0301rapeutique) avec la soci\u00e9t\u00e9 Covalab, avec qui l\u2019\u00e9quipe DesCarTes a d\u00e9velopp\u00e9 des nouveaux anticorps monoclonaux (<strong>AcMs<\/strong>) dou\u00e9s de propri\u00e9t\u00e9s th\u00e9rapeutiques ciblant des r\u00e9cepteurs de la famille du TNF.<\/p><p style=\"font-weight: 400;\"><strong><u>Domaine scientifique qui sera approfondi\u00a0<\/u><\/strong><\/p><p style=\"font-weight: 400;\">Les immunoth\u00e9rapies comme illustr\u00e9 dans la figure 1 (page suivante), rien que dans le domaine de l\u2019oncologie, sont en train de changer les paradigmes des th\u00e9rapies anticanc\u00e9reuses. Elles concerneront, dans un avenir proche plus de 30% des traitements de r\u00e9f\u00e9rence.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3dcbe6 elementor-widget elementor-widget-image\" data-id=\"c3dcbe6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"705\" src=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-1024x705.jpg\" class=\"attachment-large size-large wp-image-5455\" alt=\"\" srcset=\"https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-1024x705.jpg 1024w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-300x207.jpg 300w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-768x529.jpg 768w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-1536x1057.jpg 1536w, https:\/\/ctm.ube.fr\/wp-content\/uploads\/2024\/04\/Figure-1-ICE-2048x1410.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2956c56 elementor-widget elementor-widget-text-editor\" data-id=\"2956c56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Figure 1: Illustration sch\u00e9matique des biom\u00e9dicaments test\u00e9s en clinique ou en d\u00e9veloppement dans le domaine de l\u2019oncologie (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38448606\/\">Klein<\/a><em> et al<\/em>, 2024). L\u2019encart (Haut \u00e0 gauche), indique les antig\u00e8nes (Cibles) exprim\u00e9es par les cellulules canc\u00e9reuses faisant l\u2019objet de traitements \u00e0 base d\u2019anticorps (ie anti-PD1 et anti-PDL1 ou CAR T) chez l\u2019homme ou en d\u00e9veloppement pr\u00e9clinique (ie NK-Car T cells). <strong>CAR<\/strong> (R\u00e9cepteur activateur chim\u00e9rique), <strong>ADC<\/strong> (Anticorps conjugu\u00e9 \u00e0 un cytotoxique), <strong>ADCC<\/strong>(Cytotoxicit\u00e9 induit par un anticorps m\u00e9di\u00e9 par une interaction cellulaire), <strong>RIC<\/strong> (Radio-immunoconjugu\u00e9s). <strong>NK<\/strong> (Cellule naturellement tueuse). Les r\u00e9cepteurs de TRAIL sont repr\u00e9sent\u00e9es en Bleu (DR4 et DR5). En rouge le TNF\u03b1 et les CAR-NK cells. En Vert est repr\u00e9sent\u00e9 PDL-1, l\u2019un des antig\u00e8nes d\u2019inhibition des fonctions effectrices des lymphocytes, dont le ciblage restaure les fonctions antitumorales du syst\u00e8me immunitaire.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fc7210a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fc7210a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d2ca51a\" data-id=\"d2ca51a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ef608d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ef608d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-56cab41\" data-id=\"56cab41\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c5d9af elementor-widget elementor-widget-text-editor\" data-id=\"1c5d9af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Les cibles et les modalit\u00e9s de traitements sont nombreuses (Figure 1) mais les besoins de caract\u00e9risation et\/ou validation pr\u00e9clinique manquent encore cruellement. Notre \u00e9quipe <a href=\"https:\/\/ctm.u-bourgogne.fr\/index.php\/equipe-descartes\/\">DesCarTes<\/a> (<strong><u>De<\/u><\/strong>ath-Domain containing TNF Receptor <strong><u>S<\/u><\/strong>ignal transduction and <strong><u>Ca<\/u><\/strong>nce<strong><u>r<\/u><\/strong> <strong><u>T<\/u><\/strong>herapi<strong>es<\/strong>), lab\u00e9lis\u00e9e par l\u2019INSERM (Institut national de la sant\u00e9 et de la recherche m\u00e9dicale) au 01 Janvier 2024, s\u2019inscrit pleinement dans la politique de site du centre de recherche translationnelle en m\u00e9decine mol\u00e9culaire (CTM), dont l\u2019objectif est de transf\u00e9rer le plus rapidement possible les avanc\u00e9es m\u00e9dicales au chevet des patients. Ayant r\u00e9cemment d\u00e9velopp\u00e9 des anticorps \u00e0 fort potentiel de valorisation et partant du constat qu\u2019il n\u2019existe pas de mod\u00e8le murin humanis\u00e9 pour nos cibles d\u2019int\u00e9r\u00eat, nous proposons, dans le cadre du dispositif ICE (Itin\u00e9raire chercheur entrepreneur), un projet de th\u00e8se visant \u00e0 soutenir une initiative de cr\u00e9ation d\u2019entreprise pour d\u00e9velopper des mod\u00e8les pr\u00e9cliniques permettant des valider les th\u00e9rapies innovantes \u00e0 base d\u2019anticorps monoclonaux.<\/p><p style=\"font-weight: 400;\"><strong><u>Projet de Th\u00e8se<\/u><\/strong><\/p><p style=\"font-weight: 400;\">L&rsquo;un des principaux probl\u00e8mes des immunoth\u00e9rapies est l&rsquo;incompatibilit\u00e9 des esp\u00e8ces avec les anticorps monoclonaux, qui sont con\u00e7us pour reconna\u00eetre un motif prot\u00e9ique unique. Ainsi un anticorps ciblant un antig\u00e8ne membranaire chez l\u2019homme ne reconnaitra probablement pas ce dernier chez la souris, sauf si l\u2019\u00e9pitope reconnu est parfaitement conserv\u00e9 entre les deux esp\u00e8ces. En outre, les cibles humaines sont souvent plus complexes que chez les rongeurs chez qui certains g\u00e8nes orthologues sont quelque fois inexistants. En l\u2019occurrence, alors que TRAIL peut lier deux r\u00e9cepteurs agonistes chez l\u2019homme (DR4 et DR5), il n&rsquo;existe qu\u2019un seul r\u00e9cepteur chez les rongeurs (mTRAIL-R). Il est donc tr\u00e8s difficile, voire impossible de tester les anticorps ciblant DR4 et DR5 chez la souris, immuno-comp\u00e9tentes, et donc de mener \u00e0 bien les tests pr\u00e9cliniques, pourtant n\u00e9cessaires, pour \u00e9valuer leur efficacit\u00e9 et le cas \u00e9ch\u00e9ant leur toxicit\u00e9 potentielle, avant d\u2019\u00e9valuer leur efficacit\u00e9 chez l\u2019homme.<\/p><p style=\"font-weight: 400;\">Le projet de th\u00e8se consistera donc <strong>d\u2019une part \u00e0 g\u00e9n\u00e9rer<\/strong> avec l\u2019aide de la <a href=\"https:\/\/www.igbmc.fr\/plateformes-et-services\/infrastructures\/ics\">clinique de la souris ICS<\/a> (Strasbourg) et de l\u2019infrastructure nationale <a href=\"https:\/\/www.phenomin.fr\/en-us\/\">phenomin<\/a> <strong>une lign\u00e9e de souris \u00ab\u00a0humanis\u00e9e\u00a0\u00bb et fonctionnelle pour une cible d\u2019int\u00e9r\u00eat que nous ma\u00eetrisons dans l\u2019\u00e9quipe<\/strong>. Nous envisageons, <strong>d\u2019autre part,<\/strong> <strong>de produire des CAR-NK universels<\/strong> avec des ScFv des anticorps ciblant un ou plusieurs antig\u00e8nes tumoraux, \u00e0 partir de cellules NK d\u00e9riv\u00e9es de donneurs humains sains et de la lign\u00e9e canc\u00e9reuse NK-92, afin de tester la possibilit\u00e9 de g\u00e9n\u00e9rer des CAR NK \u00ab\u00a0universels\u00a0\u00ab\u00a0. Ce travail sera r\u00e9alis\u00e9 en \u00e9troite collaboration avec le Dr <a href=\"https:\/\/cvscience.aviesan.fr\/cv\/311\/olivier-micheau\">Olivier Micheau<\/a> (DesCarTes), le Dr <a href=\"https:\/\/faculty.mdanderson.org\/profiles\/katy_rezvani.html\">Caty Rezvani<\/a> (MD Anderson, USA) avec qui nous avons entam\u00e9 une collaboration pour utiliser ses syst\u00e8mes r\u00e9troviraux de nouvelle g\u00e9n\u00e9ration (Li<em> et al<\/em>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36175679\/\">2022<\/a>) et la soci\u00e9t\u00e9 Covalab avec qui nous avons d\u00e9j\u00e0 collabor\u00e9 (Dubuisson<em> et al.<\/em>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30718507\/\">2019<\/a>).<\/p><p style=\"font-weight: 400;\"><strong>Les applications<\/strong> de ce projet de th\u00e8se, qui s\u2019inscrit pleinement dans le Plan Innovation Sante\u0301 de<a href=\"https:\/\/www.economie.gouv.fr\/france-2030\"> France2030<\/a>, sont nombreuses et \u00e0 m\u00eame de conduire \u00e0 la cr\u00e9ation d\u2019une start-up, c\u2019est pourquoi nous recherchons une personne motiv\u00e9e et anim\u00e9e d\u2019une fibre entrepreneuriale. Ce travail de th\u00e8se est susceptible non seulement d\u2019int\u00e9resser les laboratoires acad\u00e9miques et entreprises r\u00e9gionales tels que l\u2019UMR <a href=\"https:\/\/umr-right.com\">RIGHT<\/a> U1098, <a href=\"https:\/\/www.oncodesign.com\">OPM<\/a> (Oncodesign Precision Medecine), <a href=\"https:\/\/www.oncodesign-services.com\">Oncodesign<\/a>, et <a href=\"https:\/\/abtx-bio.com\">AbTx<\/a>, mais au-del\u00e0 les grands groupes phamaceutiques et biotech impliqu\u00e9es dans la valorisation des nouvelles th\u00e9rapies innovantes.<\/p><p style=\"font-weight: 400;\"><strong><u>Bibliographie<\/u><\/strong><\/p><p>Dubuisson A, Favreau C, Fourmaux E, Lareure S, Rodrigues-Saraiva R, Pellat-Deceunynck C, El Alaoui S, Micheau O (2019) Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30718507\/\"><em>Cell death &amp; disease<\/em> <\/a>10: 101<\/p><p>Klein C, Brinkmann U, Reichert JM, Kontermann RE (2024) The present and future of bispecific antibodies for cancer therapy. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38448606\/\"><em>Nat Rev Drug Discov<\/em><\/a>: Online ahead of print.<\/p><p>Li Y, Basar R, Wang G, Liu E, Moyes JS, Li L, Kerbauy LN, Uprety N, Fathi M, Rezvan A<em> et al<\/em> (2022) KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36175679\/\"><em>Nat Med<\/em> <\/a>28: 2133-2144<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-321c238 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"321c238\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-94164c7\" data-id=\"94164c7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-674c50e elementor-widget elementor-widget-text-editor\" data-id=\"674c50e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Connaissances<\/strong>\u00a0en :<ul><li>Biologie cellulaire et mol\u00e9culaire<\/li><li>Immunologie<\/li><\/ul><\/li><li><strong>Comp\u00e9tences<\/strong>\u00a0:<ul><li>Culture cellulaire \/ Biologie mol\u00e9culaire<\/li><li>Bioinformatique<\/li><li>Cytom\u00e9trie en flux \/ microscopie<\/li><\/ul><\/li><li><strong>App\u00e9tences<\/strong> :<ul><li><span style=\"font-size: inherit;\">Fibre entrepreneuriale<\/span><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2119415\" data-id=\"2119415\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec73a83 elementor-widget elementor-widget-text-editor\" data-id=\"ec73a83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Informations\u00a0<\/strong><\/li><\/ul><div><span lang=\"EN-US\">johanna.chluba@u-bourgogne.fr et <\/span><span lang=\"EN-US\">omicheau@u-bourgogne.f<\/span><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>DISPOSITIF \u00ab\u00a0ITINERAIRE CHERCHEURS ENTREPRENEURS &#8211; ICE\u00a0\u00bb Dossier de PROJET DE THESE Ann\u00e9e 2024 Humanisation de cibles th\u00e9rapeutiques chez le rongeur pour valider les nouvelles bioth\u00e9rapies PhD Supervisor\u00a0\u00a0 : Joanna Chluba \u00a0CTM TEAM DesCarTes (Death-Domain containing TNF-receptor Signal transduction and cancer therapies) Research center :\u00a0 Center for Translational Molecular Medicine (INSERM) U1231 localisation : 7 Bd &#8230; <a title=\"PhD in the DesCarTes Team  ICE\" class=\"read-more\" href=\"https:\/\/ctm.ube.fr\/index.php\/phd-in-the-descartes-team-2\/\" aria-label=\"En savoir plus sur PhD in the DesCarTes Team  ICE\">Lire la suite<\/a><\/p>\n","protected":false},"author":27,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":""},"class_list":["post-5446","page","type-page","status-publish"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"DISPOSITIF \u00ab ITINERAIRE CHERCHEURS ENTREPRENEURS \u2013 ICE \u00bbDossier de PROJET DE THESEAnn\u00e9e 2024 Humanisation de cibles th\u00e9rapeutiques chez le rongeur pour valider les nouvelles bioth\u00e9rapies PhD Supervisor : Joanna Chluba CTM TEAM DesCarTes (Death-Domain containing TNF-receptor Signal transduction and cancer therapies)Research center : Center for Translational Molecular Medicine (INSERM) U1231 localisation : 7 Bd Jeanne d\u2019Arc, Dijon,\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" 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